Abstract 1876: NAV-001, a high-efficacy antibody-drug conjugate targeting mesothelin with improved delivery of potent payload by counteracting MUC16/CA125 effects
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-1876
Abstract: Subsets of tumor-produced proteins, referred to as Humoral Immuno-Oncology (HIO) factors, can bind to IgG1 antibodies and suppress their immune-effector activities. Antibody-drug conjugates (ADCs) targeting tumor cell surface antigens can internalize and kill target cells… read more here.
Keywords: mesothelin; muc16 ca125; hio; efficacy ... See more keywords
Iron-Induced Hepatocarcinogenesis—Preventive Effects of Nutrients
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DOI: 10.3389/fonc.2022.940552
Abstract: The liver is a primary organ that stores body iron, and plays a central role in the regulation of iron homeostasis. Hepatic iron overload (HIO) is a prevalent feature among patients with chronic liver diseases… read more here.
Keywords: iron induced; iron; hio; induced hepatocarcinogenesis ... See more keywords
Optimized serum ferritin prediction of iron overload in transfusion-dependent thalassemia: likelihood ratio and age-adjustment approach
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DOI: 10.5144/0256-4947.2023.90
Abstract: BACKGROUND: Early detection of iron overload in transfusion-dependent thalassemia (TDT) patients is critical to prevent complications and improve survival. OBJECTIVES: Evaluate the utility of serum ferritin (SF) in the prediction of hepatic and myocardial iron… read more here.
Keywords: iron overload; iron; hio; age ... See more keywords