The nutrient sensor OGT regulates Hipk stability and tumorigenic-like activities in Drosophila
Sign Up to like & getrecommendations! Published in 2020 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1912894117
Abstract: Significance O-GlcNAc transferase (OGT) transfers the sugar O-GlcNAc to serine and threonine residues of target proteins, a process known as O-GlcNAcylation. Using Drosophila as an animal model, we identify the protein kinase Hipk as a… read more here.
Keywords: protein stability; human hipk2; ogt; hipk ... See more keywords
Drosophila Homeodomain-Interacting Protein Kinase (Hipk) Phosphorylates the Hippo/Warts Signalling Effector Yorkie
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22041862
Abstract: Developmental growth and patterning are regulated by an interconnected signalling network of several pathways. In Drosophila, the Warts (Wts) kinase, a component of the Hippo signalling pathway, plays an essential role in regulating transcription and… read more here.
Keywords: kinase hipk; homeodomain interacting; kinase; hipk ... See more keywords