USP7-stabilised HIPK2 promotes high glucose-induced endothelial cell dysfunctions to accelerate diabetic foot ulcers
Sign Up to like & getrecommendations! Published in 2024 at "Archives of Physiology and Biochemistry"
DOI: 10.1080/13813455.2024.2376815
Abstract: Abstract Background This study aimed to explore the molecular mechanism of homeodomain-interacting protein kinase 2 (HIPK2) in diabetic foot ulcers (DFU). Methods High glucose (HG)-induced human umbilical vein endothelial cells (HUVECs) were used to construct… read more here.
Keywords: high glucose; stabilised hipk2; diabetic foot; usp7 stabilised ... See more keywords
Circ-HIPK2 Accelerates Cell Apoptosis and Autophagy in Myocardial Oxidative Injury by Sponging miR-485-5p and Targeting ATG101.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cardiovascular Pharmacology"
DOI: 10.1097/fjc.0000000000000879
Abstract: Myocardial injury has been deemed as a major cause of heart diseases including myocarditis and coronary heart disease, which have brought multiple mortalities globally. Long non-coding RNAs (lncRNAs) are widely recognized in diverse diseases. However,… read more here.
Keywords: circ hipk2; hipk2; injury; cell apoptosis ... See more keywords
Knockdown of HIPK2 Attenuates Angiotensin II–Induced Cardiac Fibrosis in Cardiac Fibroblasts
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cardiovascular Pharmacology"
DOI: 10.1097/fjc.0000000000001292
Abstract: Abstract: Homeodomain-interacting protein kinase-2 (HIPK2), a member of an evolutionary conserved family of serine/threonine kinases, has been observed to be involved in the pathogenesis of fibrotic diseases. However, its role in cardiac fibrosis remains unclear.… read more here.
Keywords: knockdown hipk2; cardiac fibroblasts; hipk2; cardiac fibrosis ... See more keywords
miR‐664a‐5p promotes experimental membranous nephropathy progression through HIPK2/Calpain1/GSα‐mediated autophagy inhibition
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.18074
Abstract: We previously found that miR‐664a‐5p is specifically expressed in urinary exosomes of idiopathic membranous nephropathy (IMN) patients. Homeodomain‐interacting protein kinase 2 (HIPK2), a nuclear serine/threonine kinase, plays an important role in nephropathy. But the function… read more here.
Keywords: membranous nephropathy; progression; inhibition; mir 664a ... See more keywords
HIPK2 Overexpression and Its Prognostic Role in Human Papillomavirus-Positive Tonsillar Squamous Cell Carcinoma
Sign Up to like & getrecommendations! Published in 2017 at "BioMed Research International"
DOI: 10.1155/2017/1056427
Abstract: Tonsillar squamous cell carcinomas (TSCCs) are the most common human papillomavirus- (HPV-) associated oropharyngeal cancers with poor prognosis. Homeodomain-interacting protein kinase 2 (HIPK2) is a central regulator of p53, which participates in apoptosis during the… read more here.
Keywords: squamous cell; human papillomavirus; tonsillar squamous; hipk2 overexpression ... See more keywords
Inhibition of HIPK2 Alleviates Thoracic Aortic Disease in Mice With Progressively Severe Marfan Syndrome
Sign Up to like & getrecommendations! Published in 2021 at "Arteriosclerosis, Thrombosis, and Vascular Biology"
DOI: 10.1161/atvbaha.121.316464
Abstract: Supplemental Digital Content is available in the text. Objective: Despite considerable research, the goal of finding nonsurgical remedies against thoracic aortic aneurysm and acute aortic dissection remains elusive. We sought to identify a novel aortic… read more here.
Keywords: hipk2; mice; thoracic aortic; aortic aneurysm ... See more keywords
Abstract We061: Cardiomyocytes HIPK2 Regulates Myocardial Inflammation And Heart Function Through Purinergic Signaling
Sign Up to like & getrecommendations! Published in 2024 at "Circulation Research"
DOI: 10.1161/res.135.suppl_1.we061
Abstract: Background: Homeodomain-interacting protein kinase 2 (HIPK2) is a serine/threonine kinase that belongs to an evolutionary conserved HIPK family of kinases. HIPK2-mediated regulation of the inflammation axis of signaling is a comparatively new concept. Purinergic signaling… read more here.
Keywords: purinergic signaling; function; hipk2; myocardial inflammation ... See more keywords
CircASH2L facilitates tumor-like biologic behaviours and inflammation of fibroblast-like synoviocytes via miR-129-5p/HIPK2 axis in rheumatoid arthritis
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Orthopaedic Surgery and Research"
DOI: 10.1186/s13018-021-02432-3
Abstract: Background Previous study showed that circular RNA Absent-Small-Homeotic-2--Like protein (circASH2L) was higher in rheumatoid arthritis (RA) patients. However, the roles and mechanisms of circASH2L in RA progression remain unclear. Methods Levels analysis was conducted using… read more here.
Keywords: fibroblast like; circash2l; inflammation fibroblast; mir 129 ... See more keywords
Effects of homeodomain-interacting protein kinase 2 on renal tubular epithelial cells.
Sign Up to like & getrecommendations! Published in 2020 at "European review for medical and pharmacological sciences"
DOI: 10.26355/eurrev_202006_21520
Abstract: OBJECTIVE To research the role of homeodomain-interacting protein kinase 2 (HIPK2) on the oxidative stress (OS) and apoptosis induced by hypoxia/reoxygenation (H/R) of normal rat kidney-52E (NRK-52E) cells, through the JAK2/STAT3 signaling pathway MATERIALS AND… read more here.
Keywords: homeodomain interacting; nrk 52e; 52e cells; protein kinase ... See more keywords
SIRT6 overexpression retards renal interstitial fibrosis through targeting HIPK2 in chronic kidney disease
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.1007168
Abstract: Introduction: Renal interstitial fibrosis is a common pathophysiological change in the chronic kidney disease (CKD). Nicotinamide adenine dinucleotide (NAD)-dependent deacetylase sirtuin 6 (SIRT6) is demonstrated to protect against kidney injury. Vitamin B3 is the mostly… read more here.
Keywords: hipk2; kidney; interstitial fibrosis; renal interstitial ... See more keywords
HIPK2 as a Novel Regulator of Fibrosis
Sign Up to like & getrecommendations! Published in 2023 at "Cancers"
DOI: 10.3390/cancers15041059
Abstract: Simple Summary Fibrosis can affect almost every organ and represents an increasing cause of morbidity and mortality worldwide. Despite significant progress in our understanding of the pathobiology of fibrosis, there is still a lack of… read more here.
Keywords: hipk2 novel; hipk2; novel regulator; regulator fibrosis ... See more keywords