Neuronal Hippo signaling: From development to diseases
Sign Up to like & getrecommendations! Published in 2020 at "Developmental Neurobiology"
DOI: 10.1002/dneu.22796
Abstract: Hippo signaling pathway is a highly conserved and familiar tissue growth regulator, primarily dealing with cell survival, cell proliferation, and apoptosis. The Yes‐associated protein (YAP) is the key transcriptional effector molecule, which is under negative… read more here.
Keywords: hippo; development diseases; hippo signaling; neuronal hippo ... See more keywords
Differential requirement of Hippo cascade during CTNNB1 or AXIN1 mutation‐driven hepatocarcinogenesis
Sign Up to like & getrecommendations! Published in 2022 at "Hepatology"
DOI: 10.1002/hep.32693
Abstract: Background and Aims: Gain‐of‐function (GOF) mutations of CTNNB1 and loss‐of‐function (LOF) mutations of AXIN1 are recurrent genetic alterations in hepatocellular carcinoma (HCC). We aim to investigate the functional contribution of Hippo/YAP/TAZ in GOF CTNNB1 or… read more here.
Keywords: hcc; yap taz; met sgaxin1; yap ... See more keywords
Specific ablation of Hippo signalling component Yap1 in retinal progenitors and Müller cells results in late onset retinal degeneration
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30757
Abstract: Yes‐associated protein (YAP) is a major component of the Hippo pathway involved in development, growth, repair and homeostasis. Nonsense YAP1 mutations in humans result in autosomal dominant coloboma. Here, we generated a conditional knockout mouse… read more here.
Keywords: degeneration; retinal degeneration; onset retinal; hippo ... See more keywords
Visualizing HIPPO Signaling Components in Mouse Early Embryonic Development.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8910-2_25
Abstract: The HIPPO signaling pathway plays an early and essential role in mammalian embryogenesis. The earliest known roles for HIPPO signaling during mouse development include segregating fetal and extraembryonic lineages and establishing the pluripotent progenitors of… read more here.
Keywords: hippo; hippo signaling; mouse early; cell ... See more keywords
Localization of Hippo Signaling Components in Drosophila by Fluorescence and Immunofluorescence.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8910-2_5
Abstract: Visualization of in vivo protein levels and localization is essential to analysis and elucidation of Hippo signaling mechanisms and its roles in diverse tissues. This is best done by imaging proteins using fluorescent labels. Fluorescent… read more here.
Keywords: hippo; hippo signaling; components drosophila; signaling components ... See more keywords
The clinical relevance of the Hippo pathway in pancreatic ductal adenocarcinoma
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cancer Research and Clinical Oncology"
DOI: 10.1007/s00432-020-03427-z
Abstract: The Hippo pathway has broadened in cancer research in the past decade and revealed itself to be an important driver for tumorigenesis and metastatic spread. In this study, we investigated the clinical relevance of the… read more here.
Keywords: hippo; clinical relevance; relevance hippo; pancreatic ductal ... See more keywords
A WW Tandem-Mediated Dimerization Mode of SAV1 Essential for Hippo Signaling
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2020.108118
Abstract: SUMMARY The canonical mammalian Hippo pathway contains a core kinase signaling cascade requiring upstream MST to form a stable complex with SAV1 in order to phosphorylate the downstream LATS/MOB complex. Though SAV1 dimerization is essential… read more here.
Keywords: hippo; mediated dimerization; dimerization; tandem mediated ... See more keywords
Kibra and Merlin Activate the Hippo Pathway Spatially Distinct from and Independent of Expanded.
Sign Up to like & getrecommendations! Published in 2017 at "Developmental cell"
DOI: 10.1016/j.devcel.2017.02.004
Abstract: The Hippo pathway is emerging as a key evolutionarily conserved signaling mechanism that controls organ size. Three membrane-associated proteins, Kibra, Merlin, and Expanded, regulate pathway activity, but the precise molecular mechanism by which they function… read more here.
Keywords: hippo; kibra merlin; pathway; hippo pathway ... See more keywords
Noncanonical Hippo Signalling in the Regulation of Leukocyte Function.
Sign Up to like & getrecommendations! Published in 2018 at "Trends in immunology"
DOI: 10.1016/j.it.2018.05.003
Abstract: The mammalian sterile 20-like (MST) kinases are central constituents of the evolutionary ancient canonical Hippo pathway regulating cell proliferation and survival. However, perhaps surprisingly, MST1 deficiency in human patients leads to a severe combined immunodeficiency… read more here.
Keywords: hippo; hippo signalling; noncanonical hippo; leukocyte function ... See more keywords
Phosphorylation analysis of the Hippo-YAP pathway using Phos-tag.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of proteomics"
DOI: 10.1016/j.jprot.2022.104582
Abstract: Phosphorylation is an essential regulatory mechanism in cells that modifies diverse substrates, such as proteins, carbohydrates, lipids, and nucleotides. Protein phosphorylation regulates function, subcellular localization, and protein-protein interactions. Protein kinases and phosphatases catalyze this reversible… read more here.
Keywords: hippo; protein phosphorylation; phosphorylation; phos tag ... See more keywords
A Middle Pleistocene hippo tracksite at Gombore II-2 (Melka Kunture, Upper Awash, Ethiopia)
Sign Up to like & getrecommendations! Published in 2017 at "Palaeogeography, Palaeoclimatology, Palaeoecology"
DOI: 10.1016/j.palaeo.2017.01.022
Abstract: Abstract In this paper we describe exceptionally well-preserved evidence of hippo activity at Gombore II-2, a 700,000 year-old site at Melka Kunture, at 2000 m asl in the Ethiopian highlands, in the Upper Awash Valley. We excavated and… read more here.
Keywords: hippo; melka kunture; upper awash; middle pleistocene ... See more keywords