Aberrant expression of NPPB through YAP1 and TAZ activation in mesothelioma with Hippo pathway gene alterations.
Sign Up to like & getrecommendations! Published in 2023 at "Cancer medicine"
DOI: 10.1002/cam4.6056
Abstract: BACKGROUND Mesothelioma is a neoplastic disease associated with asbestos exposure. It is highly malignant and has a poor prognosis; thus, early detection is desirable. Recent whole-genome analysis has revealed that mesothelioma is characterized by a… read more here.
Keywords: hippo pathway; pathway gene; mesothelioma patients; expression ... See more keywords
Neuronal Hippo signaling: From development to diseases
Sign Up to like & getrecommendations! Published in 2020 at "Developmental Neurobiology"
DOI: 10.1002/dneu.22796
Abstract: Hippo signaling pathway is a highly conserved and familiar tissue growth regulator, primarily dealing with cell survival, cell proliferation, and apoptosis. The Yes‐associated protein (YAP) is the key transcriptional effector molecule, which is under negative… read more here.
Keywords: hippo; development diseases; hippo signaling; neuronal hippo ... See more keywords
High mobility group protein B1 controls liver cancer initiation through yes‐associated protein ‐dependent aerobic glycolysis
Sign Up to like & getrecommendations! Published in 2018 at "Hepatology"
DOI: 10.1002/hep.29663
Abstract: Emerging studies have suggested that the Hippo pathway is involved in the tumorigenesis of hepatocellular carcinoma (HCC). However, the key regulator of the Hippo pathway in liver tumor metabolic reprogramming remains elusive. Here, we provide… read more here.
Keywords: protein; glycolysis; hif1; yap ... See more keywords
Hippo Pathway Regulation by Tyrosine Kinases.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8910-2_17
Abstract: The Hippo pathway utilizes a well-characterized Ser/Thr kinase cascade to control the downstream effectors, Yap and Taz. In addition, Yap/Taz and other Hippo pathway components are directly regulated by tyrosine kinases (TKs). The methodological strategies… read more here.
Keywords: pathway; pathway regulation; tyrosine kinases; hippo pathway ... See more keywords
Roles of RUNX in Hippo Pathway Signaling.
Sign Up to like & getrecommendations! Published in 2017 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-10-3233-2_26
Abstract: The Runt-domain (RD) transcription factors (RUNX genes) are an important family of transcriptional mediators that interact with a variety of proteins including the Hippo pathway effector proteins, YAP and TAZ. In this chapter we focus… read more here.
Keywords: runx hippo; pathway signaling; pathway; roles runx ... See more keywords
The clinical relevance of the Hippo pathway in pancreatic ductal adenocarcinoma
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cancer Research and Clinical Oncology"
DOI: 10.1007/s00432-020-03427-z
Abstract: The Hippo pathway has broadened in cancer research in the past decade and revealed itself to be an important driver for tumorigenesis and metastatic spread. In this study, we investigated the clinical relevance of the… read more here.
Keywords: hippo; clinical relevance; relevance hippo; pancreatic ductal ... See more keywords
RASSF1A–Hippo pathway link in patients with urothelial carcinoma of bladder: plausible therapeutic target
Sign Up to like & getrecommendations! Published in 2019 at "Molecular and Cellular Biochemistry"
DOI: 10.1007/s11010-019-03648-y
Abstract: RASSF1A is a tumor suppressor gene, and its hypermethylation has been observed in cancers. RASSF1A acts as an upstream regulator of Hippo pathway and modulates its function. The aim of this study was to analyze… read more here.
Keywords: rassf1a; ctgf cyr61; rassf1a hippo; hippo pathway ... See more keywords
SAHA induce hippo pathway in CCA cells without increasing cell proliferation.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular biology reports"
DOI: 10.1007/s11033-022-07204-8
Abstract: BACKGROUND Cholangiocarcinoma is a malignant tumor originating from bile duct epithelial cells. Since tumor metastasis is associated with poor prognosis and short-term survival of patients, there is an urgent need for alternative therapeutic approaches for… read more here.
Keywords: hippo pathway; induce hippo; saha induce; pathway cca ... See more keywords
The hippo pathway orchestrates cytoskeletal organisation during intervertebral disc degeneration.
Sign Up to like & getrecommendations! Published in 2021 at "Acta histochemica"
DOI: 10.1016/j.acthis.2021.151770
Abstract: Yes-associated protein (YAP) activity responded to physical and mechanical cues such as extracellular matrix (ECM), cell density and the mechanical regulation of YAP controlled cellular proliferation and inhibition of apoptotic signals. The intervertebral disc (IVD)… read more here.
Keywords: disc; intervertebral disc; yap; hippo pathway ... See more keywords
The Drosophila F-box protein Slimb controls dSmurf protein turnover to regulate the Hippo pathway.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2016.11.061
Abstract: SMAD ubiquitination regulatory factors 1 and 2 (Smurf1/2) are members of the HECT domain E3 ligase family which play crucial roles in the regulation of cell cycle progression, planar cell polarity, cancer metastasis and cell… read more here.
Keywords: protein; dsmurf; regulate hippo; hippo pathway ... See more keywords
MiR-135b promotes HCC tumorigenesis through a positive-feedback loop.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.07.008
Abstract: Hippo pathway plays critical roles in cell proliferation and apoptosis and its dysregulation leads to various types of cancers, including hepatocellular carcinoma (HCC). However, the mechanism maintaining Hippo pathway homeostasis still remains unclear. In this… read more here.
Keywords: positive feedback; mir 135b; hcc; hippo pathway ... See more keywords