The Hippo in the room: Targeting the Hippo signalling pathway for osteosarcoma therapies
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.29967
Abstract: Osteosarcoma (OS) is a primary malignant bone tumour which usually occurs in children and adolescents. OS is primarily a result of chromosomal aberrations, a combination of acquired genetic changes and, hereditary, resulting in the dysregulation… read more here.
Keywords: hippo signalling; hippo room; targeting hippo; room targeting ... See more keywords
Noncanonical Hippo Signalling in the Regulation of Leukocyte Function.
Sign Up to like & getrecommendations! Published in 2018 at "Trends in immunology"
DOI: 10.1016/j.it.2018.05.003
Abstract: The mammalian sterile 20-like (MST) kinases are central constituents of the evolutionary ancient canonical Hippo pathway regulating cell proliferation and survival. However, perhaps surprisingly, MST1 deficiency in human patients leads to a severe combined immunodeficiency… read more here.
Keywords: hippo; hippo signalling; noncanonical hippo; leukocyte function ... See more keywords
Snail regulates Hippo signalling-mediated cell proliferation and tissue growth in Drosophila
Sign Up to like & getrecommendations! Published in 2022 at "Open Biology"
DOI: 10.1098/rsob.210357
Abstract: Snail (Sna) plays a pivotal role in epithelia-mesenchymal transition and cancer metastasis, yet its functions in normal tissue development remain elusive. Here, using Drosophila as a model organism, we identified Sna as an essential regulator… read more here.
Keywords: proliferation tissue; hippo signalling; cell proliferation; tissue ... See more keywords
Suppression of long non‐coding RNA TNRC6C‐AS1 protects against thyroid carcinoma through DNA demethylation of STK4 via the Hippo signalling pathway
Sign Up to like & getrecommendations! Published in 2019 at "Cell Proliferation"
DOI: 10.1111/cpr.12564
Abstract: Thyroid carcinoma (TC) represents a malignant neoplasm affecting the thyroid. Current treatment strategies include the removal of part of the thyroid; however, this approach is associated with a significant risk of developing hypothyroidism. In order… read more here.
Keywords: signalling pathway; tnrc6c as1; thyroid carcinoma; hippo signalling ... See more keywords
Deletion of Nf2 in neural crest-derived tongue mesenchyme alters tongue shape and size, Hippo signalling and cell proliferation in a region- and stage-specific manner.
Sign Up to like & getrecommendations! Published in 2021 at "Cell proliferation"
DOI: 10.1111/cpr.13144
Abstract: OBJECTIVES The mammalian tongue develops from the branchial arches (1-4) and comprises highly organized tissues compartmentalized by mesenchyme/connective tissue that is largely derived from neural crest (NC). This study aimed to understand the roles of… read more here.
Keywords: hippo signalling; cell proliferation; proliferation; tongue ... See more keywords
83 The coronary artery disease associated gene JCAD regulates hippo signalling in endothelial cells
Sign Up to like & getrecommendations! Published in 2018 at "Heart"
DOI: 10.1136/heartjnl-2018-bcs.83
Abstract: Genome-wide association studies have associated a large number of loci with coronary artery disease (CAD) risk. The CAD-associated variants at 10 p11.23 fall in JCAD, which encodes an endothelial junction protein. We set out to investigate… read more here.
Keywords: jcad knockdown; hippo signalling; endothelial cells; jcad ... See more keywords
Association of Hippo Signalling Pathway with Epigenetic Changes in Cancer Cells and Therapeutic Approaches: An Update Review.
Sign Up to like & getrecommendations! Published in 2020 at "Anti-cancer agents in medicinal chemistry"
DOI: 10.2174/1871520620666201029112551
Abstract: Hippo signalling pathway that is an evolutionarily conserved pathway affect diver's pathology and physiology processes, including tissue repair, wound healing, tissue size and tissue regeneration. Epigenetic changes are post-translational modifications in DNA proteins and histone.… read more here.
Keywords: hippo; hippo signalling; signalling pathway; epigenetic changes ... See more keywords