Exploring Hippo YAP/TAZ Signaling: A Novel Avenue for Cardiovascular Disorders
Sign Up to like & getrecommendations! Published in 2025 at "Cell Biology International"
DOI: 10.1002/cbin.70052
Abstract: Significant attention has been paid to the Hippo signaling pathway and its effectors Yes‐associated protein (YAP) and transcriptional co‐activator with PDZ‐binding motif (TAZ) in cellular proliferation, survival, tissue homeostasis during development as well as cancer.… read more here.
Keywords: taz; cardiovascular; hippo yap; yap taz ... See more keywords
The role of Hippo‐YAP/TAZ signaling in brain development
Sign Up to like & getrecommendations! Published in 2022 at "Developmental Dynamics"
DOI: 10.1002/dvdy.504
Abstract: In order for our complex nervous system to develop normally, both precise spatial and temporal regulation of a number of different signaling pathways is critical. During both early embryogenesis and in organ development, one pathway… read more here.
Keywords: taz signaling; role; brain development; development ... See more keywords
Effect of titanium ions on the Hippo/YAP signaling pathway in regulating biological behaviors of MC3T3‐E1 osteoblasts
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.3590
Abstract: Titanium (Ti) and its corresponding alloys have been widely applied in dental and orthopedic implants. Owing to abrasion and corrosion of implants in the unfavorable electrolytic aqueous environment of the host body, Ti ions could… read more here.
Keywords: effect; signaling pathway; titanium; yap ... See more keywords
Role of the Hippo‐YAP/NF‐κB signaling pathway crosstalk in regulating biological behaviors of macrophages under titanium ion exposure
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.4065
Abstract: The presence of metal ions, such as titanium (Ti) ions, is toxic to adjacent tissues of implants. Indeed, Ti ions may induce an inflammatory response through the NF‐κB pathway, thus causing damage to soft and… read more here.
Keywords: pathway; ion exposure; yap; hippo yap ... See more keywords
Targeting Hippo/YAP in intrahepatic cholangiocarcinoma: Promising molecules in cancer therapy
Sign Up to like & getrecommendations! Published in 2024 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.23791
Abstract: The tumorigenesis of intrahepatic cholangiocarcinoma (ICC) has been identified to be exceptionally involved in dysregulated Hippo/Yes‐associated protein (YAP) signaling pathway (Hippo/YAP). Hippo/YAP functions as a master regulator engaged in a plethora of physiological and oncogenic… read more here.
Keywords: yap; yap intrahepatic; intrahepatic cholangiocarcinoma; hippo yap ... See more keywords
Decursin inhibits the growth of HepG2 hepatocellular carcinoma cells via Hippo/YAP signaling pathway
Sign Up to like & getrecommendations! Published in 2018 at "Phytotherapy Research"
DOI: 10.1002/ptr.6184
Abstract: Targeted therapy has a pivotal role for the treatment of liver cancer. The aim of this current study was to examine the effects of decursin on the growth of HepG2 cells and the underlying mechanisms.… read more here.
Keywords: decursin; growth hepg2; growth; yap signaling ... See more keywords
Recent Advances of the Hippo/YAP Signaling Pathway in Brain Development and Glioma
Sign Up to like & getrecommendations! Published in 2019 at "Cellular and Molecular Neurobiology"
DOI: 10.1007/s10571-019-00762-9
Abstract: The Hippo signaling pathway is highly conserved from Drosophila melanogaster to mammals and plays a crucial role in organ size control, tissue regeneration, and tumor suppression. The Yes-associated protein (YAP) is an important transcriptional co-activator… read more here.
Keywords: signaling pathway; yap signaling; glioma; hippo yap ... See more keywords
Morin attenuates diethylnitrosamine-induced rat liver fibrosis and hepatic stellate cell activation by co-ordinated regulation of Hippo/Yap and TGF-β1/Smad signaling.
Sign Up to like & getrecommendations! Published in 2017 at "Biochimie"
DOI: 10.1016/j.biochi.2017.05.017
Abstract: Despite great progress in understanding the activation of hepatic stellate cells (HSCs) during liver fibrosis, therapeutic approaches to inhibit HSC activation remain very limited. Recent reports highlight Yes-associated protein (Yap) and transforming growth factor-β1 (TGF-β1)… read more here.
Keywords: liver fibrosis; hippo yap; activation; tgf smad ... See more keywords
Induction of miR-15a expression by tripterygium glycosides caused premature ovarian failure by suppressing the Hippo-YAP/TAZ signaling effector Lats1.
Sign Up to like & getrecommendations! Published in 2018 at "Gene"
DOI: 10.1016/j.gene.2018.08.018
Abstract: Tripterygium glycosides (TGs) are chemotherapeutic drugs and immunosuppressant agents for the treatment of cancer and autoimmune diseases. We have previously reported that TGs induces premature ovarian failure (POF) by inducing cytotoxicity in ovarian granulosa cells… read more here.
Keywords: yap taz; expression; hippo yap; mir 15a ... See more keywords
FRMD6 determines the cell fate towards senescence: involvement of the Hippo-YAP-CCN3 axis
Sign Up to like & getrecommendations! Published in 2024 at "Cell Death and Differentiation"
DOI: 10.1038/s41418-024-01333-2
Abstract: Cellular senescence, a hallmark of aging, is pathogenically linked to the development of aging-related diseases. This study demonstrates that FRMD6, an upstream component of the Hippo/YAP signaling cascade, is a key regulator of senescence. Proteomic… read more here.
Keywords: senescence; ccn3; hippo yap; frmd6 ... See more keywords
The Hippo pathway in the heart: pivotal roles in development, disease, and regeneration
Sign Up to like & getrecommendations! Published in 2018 at "Nature Reviews Cardiology"
DOI: 10.1038/s41569-018-0063-3
Abstract: The Hippo–YAP (Yes-associated protein) pathway is an evolutionarily and functionally conserved regulator of organ size and growth with crucial roles in cell proliferation, apoptosis, and differentiation. This pathway has great potential for therapeutic manipulation in… read more here.
Keywords: yap pathway; hippo; heart; regeneration ... See more keywords