Effects of microRNA‐206 and its target gene IGF‐1 on sevoflurane‐induced activation of hippocampal astrocytes in aged rats through the PI3K/AKT/CREB signaling pathway
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DOI: 10.1002/jcp.26248
Abstract: The study aims to explore the effects of microRNA‐206 (miR‐206) targeting IGF‐1 on the activation of hippocampal astrocytes in aged rats induced by sevoflurane through the PI3K/AKT/CREB signaling pathway. Wistar rats and astrocytes were divided… read more here.
Keywords: akt creb; mir 206; pi3k akt; activation hippocampal ... See more keywords
Immortalised Hippocampal Astrocytes from 3xTG-AD Mice Fail to Support BBB Integrity In Vitro: Role of Extracellular Vesicles in Glial-Endothelial Communication
Sign Up to like & getrecommendations! Published in 2020 at "Cellular and Molecular Neurobiology"
DOI: 10.1007/s10571-020-00871-w
Abstract: Impairments of the blood–brain barrier (BBB) and vascular dysfunction contribute to Alzheimer’s disease (AD) from the earliest stages. However, the influence of AD-affected astrocytes on the BBB remain largely unexplored. In the present study, we created… read more here.
Keywords: extracellular vesicles; bbb; astrocytes 3xtg; 3tg iastro ... See more keywords
Subfield‐specific effects of chronic mild unpredictable stress on hippocampal astrocytes
Sign Up to like & getrecommendations! Published in 2021 at "European Journal of Neuroscience"
DOI: 10.1111/ejn.15234
Abstract: Major depressive disorder (MDD) is a debilitating neuropsychiatric illness affecting over 20% of the population worldwide. Despite its prevalence, our understanding of its pathophysiology is severely limited, thus hampering the development of novel therapeutic strategies.… read more here.
Keywords: mild unpredictable; unpredictable stress; stress; chronic mild ... See more keywords
Dexmedetomidine attenuates propofol‐induced apoptosis of neonatal hippocampal astrocytes by inhibiting the Bcl2l1 signalling pathway
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DOI: 10.1111/ejn.15517
Abstract: Apoptosis shapes brain structure and function during early life. However, aberrant apoptosis, including that associated with the general anaesthetic propofol, is undesirable. Dexmedetomidine (DEX) provides potential neuroprotection against apoptosis, but the underlying mechanism remains unknown.… read more here.
Keywords: dexmedetomidine attenuates; apoptosis; hippocampal astrocytes; bcl2l1 ... See more keywords
Modeling the heterogeneity of sodium and calcium homeostasis between cortical and hippocampal astrocytes and its impact on bioenergetics
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2023.1035553
Abstract: Emerging evidence indicates that neuronal activity-evoked changes in sodium concentration in astrocytes Naa represent a special form of excitability, which is tightly linked to all other major ions in the astrocyte and extracellular space, as… read more here.
Keywords: hippocampal astrocytes; heterogeneity; modeling heterogeneity; heterogeneity sodium ... See more keywords
Comparative assessment of the effects of DREADDs and endogenously expressed GPCRs in hippocampal astrocytes on synaptic activity and memory
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2023.1159756
Abstract: Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) have proven themselves as one of the key in vivo techniques of modern neuroscience, allowing for unprecedented access to cellular manipulations in living animals. With respect to… read more here.
Keywords: hippocampal astrocytes; astrocytes synaptic; activity memory; synaptic activity ... See more keywords
The Masticatory Activity Interference in Quantitative Estimation of CA1, CA3 and Dentate Gyrus Hippocampal Astrocytes of Aged Murine Models and under Environmental Stimulation
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24076529
Abstract: Studies indicating the influence of masticatory dysfunction, due to a soft diet or lack of molars, on impairing spatial memory and learning have led to research about neuronal connections between areas and cell populations possibly… read more here.
Keywords: masticatory activity; activity; dentate gyrus; hippocampal astrocytes ... See more keywords