Helical tomotherapy was superior to intensity-modulated radiation therapy in hippocampal avoidance prophylactic cranial irradiation in patients with limited-stage small-cell lung cancer.
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DOI: 10.1200/jco.2024.42.16_suppl.e20099
Abstract: e20099 Background: Hippocampal avoidance (HA) techniques have been developed to reduce the risk of neurocognitive dysfunction associated with prophylactic cranial irradiation (PCI) in patients with limited-stage small-cell lung cancer (LS-SCLC). However, applying different radiotherapy techniques… read more here.
Keywords: hippocampal avoidance; cancer; cranial irradiation; tomo ... See more keywords
Randomized Phase III Trial of Prophylactic Cranial Irradiation With or Without Hippocampal Avoidance for Small-Cell Lung Cancer (PREMER): A GICOR-GOECP-SEOR Study
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DOI: 10.1200/jco.21.00639
Abstract: PURPOSE Radiation dose received by the neural stem cells of the hippocampus during whole-brain radiotherapy has been associated with neurocognitive decline. The key concern using hippocampal avoidance-prophylactic cranial irradiation (HA-PCI) in patients with small-cell lung… read more here.
Keywords: hippocampal avoidance; brain; cranial irradiation; prophylactic cranial ... See more keywords