Orexin‐A increases the firing activity of hippocampal CA1 neurons through orexin‐1 receptors
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.23975
Abstract: Orexins including two peptides, orexin‐A and orexin‐B, are produced in the posterior lateral hypothalamus. Much evidence has indicated that central orexinergic systems play numerous functions including energy metabolism, feeding behavior, sleep/wakefulness, and neuroendocrine and sympathetic… read more here.
Keywords: orexin; ca1 neurons; ca1; firing activity ... See more keywords
Hydromorphone protects CA1 neurons by activating mTOR pathway
Sign Up to like & getrecommendations! Published in 2018 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2018.09.029
Abstract: Hydromorphone has been shown to play protective effect in rat glial cell. However, whether hydromorphone plays important roles in ischemia-reperfusion (IR) injury and the involved signaling pathway remains unclear. In this study, we detected whether… read more here.
Keywords: ca1 neurons; hydromorphone; pathway; activating mtor ... See more keywords
Differential involvement of Ca2+/calmodulin-dependent protein kinases and mitogen-activated protein kinases in the dopamine D1/D5 receptor-mediated potentiation in hippocampal CA1 pyramidal neurons
Sign Up to like & getrecommendations! Published in 2017 at "Neurobiology of Learning and Memory"
DOI: 10.1016/j.nlm.2016.07.020
Abstract: HighlightsD1/D5 receptor‐dependent LTP (DA‐LTP) in CA1 region is MEK/MAPK pathway dependent.Here we studied the differential role of CaMKs and MEKs during DA‐LTP.With weak dopaminergic activation, both CaMKII and MEKs were necessary for DA‐LTP.During stronger dopaminergic… read more here.
Keywords: potentiation; protein kinases; activation; hippocampal ca1 ... See more keywords
Chronic altered light–dark cycle differentially affects hippocampal CA1 and DG neuronal arborization in diurnal and nocturnal rodents
Sign Up to like & getrecommendations! Published in 2022 at "Chronobiology International"
DOI: 10.1080/07420528.2021.2023561
Abstract: ABSTRACT The hippocampus, an extension of the temporal part of the cerebral cortex, plays a crucial role in learning and memory. Structural and functional complexity within the hippocampus is greatly affected by a variety of… read more here.
Keywords: cycle; dark cycle; hippocampal ca1; light dark ... See more keywords
The Entorhinal Cortical Alvear Pathway Differentially Excites Pyramidal Cells and Interneuron Subtypes in Hippocampal CA1.
Sign Up to like & getrecommendations! Published in 2020 at "Cerebral cortex"
DOI: 10.1093/cercor/bhaa359
Abstract: The entorhinal cortex alvear pathway is a major excitatory input to hippocampal CA1, yet nothing is known about its physiological impact. We investigated the alvear pathway projection and innervation of neurons in CA1 using optogenetics… read more here.
Keywords: ca1; alvear pathway; entorhinal cortical; pyramidal cells ... See more keywords
Persistent Firing in Hippocampal CA1 Pyramidal Cells in Young and Aged Rats
Sign Up to like & getrecommendations! Published in 2023 at "eNeuro"
DOI: 10.1523/eneuro.0479-22.2023
Abstract: Abstract Persistent neuronal firing is often observed in working memory and temporal association tasks both in humans and animals, and is believed to retain necessary information in these tasks. We have reported that hippocampal CA1… read more here.
Keywords: aged rats; ca1 pyramidal; hippocampal ca1; persistent firing ... See more keywords
Calcium Dynamics in Dendrites of Hippocampal CA1 Interneurons in Awake Mice
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2019.00098
Abstract: Hippocampal inhibitory interneurons exhibit a large diversity of dendritic Ca2+ mechanisms that are involved in the induction of Hebbian and anti-Hebbian synaptic plasticity. High resolution imaging techniques allowed examining somatic Ca2+ signals and, accordingly, the… read more here.
Keywords: interneurons awake; dendritic ca2; ca2; ca1 interneurons ... See more keywords
Expression changes of CX3CL1 and CX3CR1 proteins in the hippocampal CA1 field of the gerbil following transient global cerebral ischemia
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Molecular Medicine"
DOI: 10.3892/ijmm.2019.4273
Abstract: Chemokine C-X3-C motif ligand 1 (CX3CL1) and its sole receptor, CX3CR1, are known to be involved in neuronal damage/death following brain ischemia. In the present study, time-dependent expression changes of CX3CL1 and CX3CR1 proteins were… read more here.
Keywords: cx3cr1 proteins; expression changes; expression; changes cx3cl1 ... See more keywords
Less hippocampal neuronal death in young gerbils following transient global cerebral ischemia is associated with long-term maintenance of insulin-like growth factor 1 and its receptors in the hippocampal CA1 region
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Medicine Reports"
DOI: 10.3892/mmr.2017.8243
Abstract: Insulin-like growth factor 1 (IGF-1) is a well-known growth factor with well-defined neuroprotective effects against cerebral ischemia. However, the age-dependent differences in the expression of IGF-1 and its receptor (IGF-1R) in the brain following transient… read more here.
Keywords: adult; ca1 region; cerebral ischemia; growth factor ... See more keywords
Effect of Neuronal Excitability in Hippocampal CA1 Area on Auditory Pathway in a Rat Model of Tinnitus
Sign Up to like & getrecommendations! Published in 2018 at "Chinese Medical Journal"
DOI: 10.4103/0366-6999.238148
Abstract: Background: Tinnitus is a common disorder that causes significant morbidity; however, the neurophysiological mechanism is not yet fully understood. A relationship between tinnitus and limbic system has been reported. As a significant component of the… read more here.
Keywords: hippocampus; ca1 area; excitability; tinnitus ... See more keywords
Cranial irradiation impairs intrinsic excitability and synaptic plasticity of hippocampal CA1 pyramidal neurons with implications for cognitive function
Sign Up to like & getrecommendations! Published in 2022 at "Neural Regeneration Research"
DOI: 10.4103/1673-5374.336875
Abstract: Radiation therapy is a standard treatment for head and neck tumors. However, patients often exhibit cognitive impairments following radiation therapy. Previous studies have revealed that hippocampal dysfunction, specifically abnormal hippocampal neurogenesis or neuroinflammation, plays a… read more here.
Keywords: pyramidal neurons; synaptic plasticity; ca1 pyramidal; hippocampal ca1 ... See more keywords