Epigenetic suppression of hippocampal calbindin-D28k by ΔFosB drives seizure-related cognitive deficits
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DOI: 10.1038/nm.4413
Abstract: The calcium-binding protein calbindin-D28k is critical for hippocampal function and cognition, but its expression is markedly decreased in various neurological disorders associated with epileptiform activity and seizures. In Alzheimer's disease (AD) and epilepsy, both of… read more here.
Keywords: cognitive deficits; calbindin d28k; fosb; expression ... See more keywords