Neonatal infection produces significant changes in immune function with no associated learning deficits in juvenile rats
Sign Up to like & getrecommendations! Published in 2017 at "Developmental Neurobiology"
DOI: 10.1002/dneu.22512
Abstract: The current experiments examined the impact of early‐life immune activation and a subsequent mild immune challenge with lipopolysaccharide (LPS; 25µg/kg) on hippocampal‐dependent learning, proinflammatory cytokine expression in the brain, and peripheral immune function in juvenile… read more here.
Keywords: infection; expression; juvenile; learning deficits ... See more keywords
Adeno-associated viral overexpression of neuroligin 2 in the mouse hippocampus enhances GABAergic synapses and impairs hippocampal-dependent behaviors
Sign Up to like & getrecommendations! Published in 2019 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2018.12.052
Abstract: Graphical abstract Figure. No Caption available. ABSTRACT The cell adhesion molecule neuroligin2 (NLGN2) regulates GABAergic synapse development, but its role in neural circuit function in the adult hippocampus is unclear. We investigated GABAergic synapses and… read more here.
Keywords: dependent behaviors; overexpression; hippocampus; adeno associated ... See more keywords
‘Real-life’ hippocampal-dependent spatial memory impairments in Huntington's disease
Sign Up to like & getrecommendations! Published in 2019 at "Cortex"
DOI: 10.1016/j.cortex.2019.04.006
Abstract: Hippocampal-dependent spatial memory impairments are seen in Huntington's disease animal models. Similar impairments were recently reported in Huntington's disease participants on analogous spatial memory tasks (e.g., virtual Morris Water Maze), however, these tasks do not… read more here.
Keywords: spatial memory; hippocampal dependent; huntington disease; disease ... See more keywords
Ca2+-Binding Protein 1 Regulates Hippocampal-dependent Memory and Synaptic Plasticity
Sign Up to like & getrecommendations! Published in 2018 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2018.04.004
Abstract: Ca2+-binding protein 1 (CaBP1) is a Ca2+-sensing protein similar to calmodulin that potently regulates voltage-gated Ca2+ channels. Unlike calmodulin, however, CaBP1 is mainly expressed in neuronal cell-types and enriched in the hippocampus, where its function… read more here.
Keywords: protein; cabp1; ca2 binding; binding protein ... See more keywords
Déjà-vu? Neural and behavioural effects of the 5-HT4 receptor agonist, prucalopride, in a hippocampal-dependent memory task
Sign Up to like & getrecommendations! Published in 2021 at "Translational Psychiatry"
DOI: 10.1038/s41398-021-01568-4
Abstract: Cognitive deficits commonly accompany psychiatric disorders but are often underrecognised, and difficult to treat. The 5-HT4 receptor is a promising potential treatment target for cognitive impairment because in animal studies 5-HT4 receptor agonists enhance hippocampal-dependent… read more here.
Keywords: ht4 receptor; dependent memory; agonist prucalopride; receptor ... See more keywords
Subicular neurons represent multiple variables of a hippocampal-dependent task by using theta rhythm
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Biology"
DOI: 10.1371/journal.pbio.3001546
Abstract: The subiculum is positioned at a critical juncture at the interface of the hippocampus with the rest of the brain. However, the exact roles of the subiculum in most hippocampal-dependent memory tasks remain largely unknown.… read more here.
Keywords: hippocampal dependent; theta rhythm; task; using theta ... See more keywords
Cortico-Hippocampal Oscillations Are Associated With the Developmental Onset of Hippocampal-Dependent Memory
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2022.891523
Abstract: Hippocampal-dependent memories emerge late during postnatal development, aligning with hippocampal maturation. During sleep, the two-stage memory formation model states that through hippocampal-neocortical interactions, cortical slow-oscillations (SO), thalamocortical Spindles, and hippocampal sharp-wave ripples (SWR) are synchronized,… read more here.
Keywords: hippocampal dependent; dependent memory; onset hippocampal; cortico hippocampal ... See more keywords
The Effect of Dietary Fat and Sucrose on Cognitive Functioning in Mice Lacking Insulin Signaling in Neuropeptide Y Neurons
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2022.841935
Abstract: Obesogenic diets can produce hippocampal insulin resistance and impairments to hippocampal-dependent cognition. This study investigated the effect of disrupted insulin signaling in Neuropeptide Y (NPY) neurons on diet-induced deficits in hippocampal-dependent memory. Wild-type mice and… read more here.
Keywords: insulin signaling; hippocampal dependent; effect; fat ... See more keywords