Sparsification of AP firing in adult-born hippocampal granule cells via voltage-dependent α5-GABAA receptors.
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.109768
Abstract: GABA can depolarize immature neurons close to the action potential (AP) threshold in development and adult neurogenesis. Nevertheless, GABAergic synapses effectively inhibit AP firing in newborn granule cells of the adult hippocampus as early as… read more here.
Keywords: adult; hippocampal granule; voltage dependent; gabaa receptors ... See more keywords
Oxidative-Stress-Associated Proteostasis Disturbances and Increased DNA Damage in the Hippocampal Granule Cells of the Ts65Dn Model of Down Syndrome
Sign Up to like & getrecommendations! Published in 2022 at "Antioxidants"
DOI: 10.3390/antiox11122438
Abstract: Oxidative stress (OS) is one of the neuropathological mechanisms responsible for the deficits in cognition and neuronal function in Down syndrome (DS). The Ts65Dn (TS) mouse replicates multiple DS phenotypes including hippocampal-dependent learning and memory… read more here.
Keywords: increased dna; hippocampal granule; damage; dna damage ... See more keywords
Dendritic spikes in hippocampal granule cells are necessary for long-term potentiation at the perforant path synapse
Sign Up to like & getrecommendations! Published in 2018 at "eLife"
DOI: 10.7554/elife.35269
Abstract: Long-term potentiation (LTP) of synaptic responses is essential for hippocampal memory function. Perforant-path (PP) synapses on hippocampal granule cells (GCs) contribute to the formation of associative memories, which are considered the cellular correlates of memory… read more here.
Keywords: term potentiation; dendritic spikes; long term; hippocampal granule ... See more keywords