Intermittent fasting increases adult hippocampal neurogenesis
Sign Up to like & getrecommendations! Published in 2019 at "Brain and Behavior"
DOI: 10.1002/brb3.1444
Abstract: Intermittent fasting (IF) has been suggested to have neuroprotective effects through the activation of multiple signaling pathways. Rodents fasted intermittently exhibit enhanced hippocampal neurogenesis and long‐term potentiation (LTP) at hippocampal synapses compared with sedentary animals… read more here.
Keywords: fasting increases; neurogenesis; hippocampal neurogenesis; intermittent fasting ... See more keywords
Hippocampal neurogenesis promotes effortful responding but does not regulate effort‐based choice
Sign Up to like & getrecommendations! Published in 2022 at "Hippocampus"
DOI: 10.1002/hipo.23472
Abstract: A fundamental trait of depression is low motivation. Hippocampal neurogenesis has been associated with motivational deficits but detailed evidence on how it regulates human‐relevant behavioral traits is still missing. We used the hGFAP‐TK rat model… read more here.
Keywords: hippocampal neurogenesis; based choice; neurogenesis; effort based ... See more keywords
Methods to study adult hippocampal neurogenesis in humans and across the phylogeny
Sign Up to like & getrecommendations! Published in 2022 at "Hippocampus"
DOI: 10.1002/hipo.23474
Abstract: The hippocampus hosts the continuous addition of new neurons throughout life—a phenomenon named adult hippocampal neurogenesis (AHN). Here we revisit the occurrence of AHN in more than 110 mammalian species, including humans, and discuss the… read more here.
Keywords: hippocampal neurogenesis; adult hippocampal; ahn; methodology ... See more keywords
Early fate bias in neuroepithelial progenitors of hippocampal neurogenesis
Sign Up to like & getrecommendations! Published in 2022 at "Hippocampus"
DOI: 10.1002/hipo.23482
Abstract: Hippocampal adult neural stem cells emerge from progeny of the neuroepithelial lineage during murine brain development. Hippocampus development is increasingly well understood. However, the clonal relationships between early neuroepithelial stem cells and postnatal neurogenic cells… read more here.
Keywords: fate; early fate; fate bias; hippocampal neurogenesis ... See more keywords
In vitro characterization on the role of APOE polymorphism in human hippocampal neurogenesis
Sign Up to like & getrecommendations! Published in 2023 at "Hippocampus"
DOI: 10.1002/hipo.23502
Abstract: Hippocampal neurogenesis (HN) is considered an important mechanism underlying lifelong brain plasticity, and alterations in this process have been implicated in early Alzheimer's disease progression. APOE polymorphism is the most common genetic risk factor for… read more here.
Keywords: apoe polymorphism; polymorphism; role; neurogenesis ... See more keywords
Mechanisms underlying the effect of voluntary running on adult hippocampal neurogenesis
Sign Up to like & getrecommendations! Published in 2023 at "Hippocampus"
DOI: 10.1002/hipo.23520
Abstract: Adult hippocampal neurogenesis is important for preserving learning and memory‐related cognitive functions. Physical exercise, especially voluntary running, is one of the strongest stimuli to promote neurogenesis and has beneficial effects on cognitive functions. Voluntary running… read more here.
Keywords: adult hippocampal; mechanisms underlying; neurogenesis; hippocampal neurogenesis ... See more keywords
Oral exposure to aluminum chloride for 28 days suppresses neural stem cell proliferation and increases mature granule cells in adult hippocampal neurogenesis of young‐adult rats
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.4299
Abstract: Aluminum (Al), a common light metal, affects the developing nervous system. Developmental exposure to Al chloride (AlCl3) induces aberrant neurogenesis by targeting neural stem cells (NSCs) and/or neural progenitor cells (NPCs) in the dentate gyrus… read more here.
Keywords: hippocampal neurogenesis; mature granule; exposure; granule cells ... See more keywords
A Preview of Selected Articles ‐ August 2018
Sign Up to like & getrecommendations! Published in 2018 at "STEM CELLS"
DOI: 10.1002/stem.2867
Abstract: In 2007, two groundbreaking studies describing the first generation of human induced pluripotent stem cells (hiPSCs) revolutionized the world of stem cells and regenerative medicine. Researchers from the group of Shinya Yamanaka employed OCT4, SOX2,… read more here.
Keywords: selected articles; article; hippocampal neurogenesis; preview selected ... See more keywords
Saikosaponin D relieves unpredictable chronic mild stress induced depressive-like behavior in rats: involvement of HPA axis and hippocampal neurogenesis
Sign Up to like & getrecommendations! Published in 2017 at "Psychopharmacology"
DOI: 10.1007/s00213-017-4720-8
Abstract: RationaleSaikosaponin D (SSD), a major bioactive component isolated from Radix Bupleuri, has been reported to exert neuroprotective properties.ObjectivesThe present study was designed to investigate the anti-depressant-like effects and the potential mechanisms of SSD.MethodsBehavioural tests including… read more here.
Keywords: hippocampal neurogenesis; unpredictable chronic; chronic mild; hpa axis ... See more keywords
Adaptor Protein APPL2 Affects Adult Antidepressant Behaviors and Hippocampal Neurogenesis via Regulating the Sensitivity of Glucocorticoid Receptor
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Neurobiology"
DOI: 10.1007/s12035-017-0785-y
Abstract: Adaptor proteins containing the pleckstrin homology domain, phosphotyrosine binding domain, and leucine zipper motif (APPLs) are multifunctional adaptor proteins involved in regulating many biological activities and processes. The newly identified metabolic factor APPL2 showed the… read more here.
Keywords: appl2; neurogenesis; hippocampal neurogenesis; glucocorticoid receptor ... See more keywords
Targeting impaired adult hippocampal neurogenesis in ageing by leveraging intrinsic mechanisms regulating Neural Stem Cell activity
Sign Up to like & getrecommendations! Published in 2021 at "Ageing Research Reviews"
DOI: 10.1016/j.arr.2021.101447
Abstract: Deficits in adult neurogenesis may contribute to the aetiology of many neurodevelopmental, psychiatric and neurodegenerative diseases. Genetic ablation of neurogenesis provides proof of concept that adult neurogenesis is required to sustain complex and dynamic cognitive… read more here.
Keywords: adult; neurogenesis; hippocampal neurogenesis; adult hippocampal ... See more keywords