MicroRNA‐25 aggravates Aβ1‐42‐induced hippocampal neuron injury in Alzheimer's disease by downregulating KLF2 via the Nrf2 signaling pathway in a mouse model
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.28861
Abstract: Recently, numerous microRNAs (miRNAs) have been considered as key players in the regulation of neuronal processes. The purpose of the present study is to explore the effect of miR‐25 on hippocampal neuron injury in Alzheimer's… read more here.
Keywords: mir; neuron injury; nrf2 signaling; signaling pathway ... See more keywords
Differential α-synuclein expression contributes to selective vulnerability of hippocampal neuron subpopulations to fibril-induced toxicity
Sign Up to like & getrecommendations! Published in 2018 at "Acta Neuropathologica"
DOI: 10.1007/s00401-018-1829-8
Abstract: The accumulation of misfolded α-synuclein (aSyn) and neuron loss define several neurodegenerative disorders including Parkinson’s disease (PD) and dementia with Lewy bodies (DLB). However, the precise relationship between pathology and neurotoxicity and why these processes… read more here.
Keywords: selective vulnerability; pathology; toxicity; hippocampal neuron ... See more keywords
MicroRNA-153 promotes brain-derived neurotrophic factor and hippocampal neuron proliferation to alleviate autism symptoms through inhibition of JAK-STAT pathway by LEPR
Sign Up to like & getrecommendations! Published in 2019 at "Bioscience Reports"
DOI: 10.1042/bsr20181904
Abstract: Autism is known as a severe neurobehavioral syndrome, with males affected more often than females. Previous studies have revealed that microRNAs (miRNAs) play a critical role in the search for novel therapeutic strategies for autism.… read more here.
Keywords: hippocampal neuron; jak; autism; jak stat ... See more keywords
The molecular mechanism underlying mitophagy‐mediated hippocampal neuron apoptosis in diabetes‐related depression
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.16763
Abstract: Diabetes‐related depression (DD) is a major complication of diabetes mellitus. Our previous studies indicated that glutamate (Glu) and hippocampal neuron apoptosis are key signal and direct factor leading to diabetes‐related depression, respectively. However, the accurate… read more here.
Keywords: apoptosis; related depression; neuron apoptosis; hippocampal neuron ... See more keywords
m6A Methyltransferase METTL3 Reduces Hippocampal Neuron Apoptosis in a Mouse Model of Autism Through the MALAT1/SFRP2/Wnt/β-catenin Axis
Sign Up to like & getrecommendations! Published in 2022 at "Psychiatry Investigation"
DOI: 10.30773/pi.2021.0370
Abstract: Objective Hippocampal neuron apoptosis contributes to autism, while METTL3 has been documented to possess great potentials in neuron apoptosis. Our study probed into the role of METTL3 in neuron apoptosis in autism and to determine… read more here.
Keywords: autism; neuron apoptosis; hippocampal neuron; wnt catenin ... See more keywords
Dl-3-n-Butylphthalide Reduces Cognitive Impairment Induced by Chronic Cerebral Hypoperfusion Through GDNF/GFRα1/Ret Signaling Preventing Hippocampal Neuron Apoptosis
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2019.00351
Abstract: Hippocampal neuron death is a key factor in vascular dementia (VD) induced by chronic cerebral hypoperfusion (CCH). Dl-3-n-butylphthalide (NBP) is a multiple-effects drug. Therefore, the potential molecular mechanisms underlying CCH and its feasible treatment should… read more here.
Keywords: gdnf gfr; hippocampal neuron; gfr ret; ret ... See more keywords
Effects of Caloric Restriction on Spatial Object Recognition Memory, Hippocampal Neuron Loss and Neuroinflammation in Aged Rats
Sign Up to like & getrecommendations! Published in 2023 at "Nutrients"
DOI: 10.3390/nu15071572
Abstract: Age-related neurobiological changes significantly affect hippocampal structure and function, such that the main cognitive impairments associated with aging are related to the integrity of this brain structure, including the deterioration in spatial object recognition (SOR)… read more here.
Keywords: hippocampal neuron; spatial object; neuron loss; loss ... See more keywords
Resveratrol ameliorates depressive disorder through the NETRIN1-mediated extracellular signal-regulated kinase/cAMP signal transduction pathway.
Sign Up to like & getrecommendations! Published in 2018 at "Molecular medicine reports"
DOI: 10.3892/mmr.2018.8379
Abstract: Depressive disorder is a mental health disorder caused by the dysfunction of nerve regeneration, neuroendocrine and neurobiochemistry, which frequently results in cognitive impairments and disorder. Evidence has shown that resveratrol offers benefits for the treatment… read more here.
Keywords: resveratrol; depressive disorder; treatment; disorder ... See more keywords