Fibroblast Growth Factor 2‐Mediated Regulation of Neuronal Exosome Release Depends on VAMP3/Cellubrevin in Hippocampal Neurons
Sign Up to like & getrecommendations! Published in 2020 at "Advanced Science"
DOI: 10.1002/advs.201902372
Abstract: Abstract Extracellular vesicles (EVs) are endogenous membrane‐derived vesicles that shuttle bioactive molecules between glia and neurons, thereby promoting neuronal survival and plasticity in the central nervous system (CNS) and contributing to neurodegenerative conditions. Although EVs… read more here.
Keywords: vamp3 cellubrevin; hippocampal neurons; fibroblast growth; growth factor ... See more keywords
miR‐139‐5p upregulation alleviated spontaneous recurrent epileptiform discharge‐induced oxidative stress and apoptosis in rat hippocampal neurons via regulating the Notch pathway
Sign Up to like & getrecommendations! Published in 2020 at "Cell Biology International"
DOI: 10.1002/cbin.11509
Abstract: Epilepsy was characterized by the occurrence of spontaneous recurrent epileptiform discharges (SREDs) in neurons. Previous studies suggested that microRNA (miR)−139‐5p and the Notch pathway were implicated in epilepsy; however, their interaction remained vague. Rat primary… read more here.
Keywords: mir 139; hippocampal neurons; apoptosis; 139 upregulation ... See more keywords
CREG mitigates neonatal HIE injury through survival promotion and apoptosis inhibition in hippocampal neurons via activating AKT signaling
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biology International"
DOI: 10.1002/cbin.11777
Abstract: Neonatal hypoxic ischemic encephalopathy (Neonatal HIE) is a common but serious disease caused by perinatal asphyxia injury in newborns. Elevated neuronal apoptosis plays an important role in the injury process post hypoxia ischemia of the… read more here.
Keywords: apoptosis; akt signaling; neonatal hie; hippocampal neurons ... See more keywords
Effects of GABAB receptor positive allosteric modulator BHF177 and IRS‐1 on apoptosis of hippocampal neurons in rats with refractory epilepsy via the PI3K/Akt pathway
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biology International"
DOI: 10.1002/cbin.11839
Abstract: The present study was conducted to determine the effects of the γ‐aminobutyric acid B (GABAB) receptor positive allosteric modulator BHF177 on refractory epilepsy (RE). An RE rat model was initially established via treatment with lithium‐pilocarpine.… read more here.
Keywords: pi3k akt; apoptosis; gabab receptor; hippocampal neurons ... See more keywords
Caveolin‐1 suppresses hippocampal neuron apoptosis via the regulation of HIF1α in hypoxia in naked mole‐rats
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biology International"
DOI: 10.1002/cbin.11890
Abstract: Naked mole‐rats (NMRs) (Heterocephalus glaber) are highly social and subterranean rodents with large communal colonies in burrows containing low oxygen levels. The inhibition of severe hypoxic conditions is of particular interest to this study. To… read more here.
Keywords: naked mole; nmr hippocampal; hypoxia; cav ... See more keywords
Effect of tramadol on apoptosis and synaptogenesis in hippocampal neurons: The possible role of µ‐opioid receptor
Sign Up to like & getrecommendations! Published in 2022 at "Drug Development Research"
DOI: 10.1002/ddr.21973
Abstract: Tramadol is a synthetic opioid with centrally acting analgesic activity that alleviates moderate to severe pain and treats withdrawal symptoms of the other opioids. Like other opioid drugs, tramadol abuse has adverse effects on central… read more here.
Keywords: apoptosis synaptogenesis; effect; tramadol; hippocampal neurons ... See more keywords
CCL17 exerts a neuroimmune modulatory function and is expressed in hippocampal neurons
Sign Up to like & getrecommendations! Published in 2018 at "Glia"
DOI: 10.1002/glia.23507
Abstract: Chemokines are important signaling molecules in the immune and nervous system. Using a fluorescence reporter mouse model, we demonstrate that the chemokine CCL17, a ligand of the chemokine receptor CCR4, is produced in the murine… read more here.
Keywords: hippocampal neurons; neuroimmune modulatory; exerts neuroimmune; ccl17 exerts ... See more keywords
Distinct roles of Bdnf I and Bdnf IV transcript variant expression in hippocampal neurons
Sign Up to like & getrecommendations! Published in 2024 at "Hippocampus"
DOI: 10.1002/hipo.23600
Abstract: Brain‐derived neurotrophic factor (Bdnf) plays a critical role in brain development, dendritic growth, synaptic plasticity, as well as learning and memory. The rodent Bdnf gene contains nine 5′ non‐coding exons (I–IXa), which are spliced to… read more here.
Keywords: bdnf bdnf; hippocampal neurons; bdnf; bdnf transcript ... See more keywords
MicroRNA‐421 suppresses the apoptosis and autophagy of hippocampal neurons in epilepsy mice model by inhibition of the TLR/MYD88 pathway
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.26498
Abstract: Epilepsy is a group of neurological disorders characterized by epileptic seizures. In this study, we aim to explore the role of microRNA‐421 (miR‐421) in hippocampal neurons of epilepsy mice via the TLR/MYD88 pathway. Forty mice… read more here.
Keywords: hippocampal neurons; tlr myd88; neurons epilepsy; model ... See more keywords
MTEP impedes the neuronal polarization and the activity of the Akt–NF‐κB pathway in rat hippocampal neurons
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.24002
Abstract: Metabotropic glutamate receptor 5 (mGluR5) is extensively involved in neural survival, differentiation, dendritic morphology, synaptic plasticity, and neural circuit formation. However, little is known about its role in neuronal polarization and axon outgrowth. In this… read more here.
Keywords: hippocampal neurons; axon outgrowth; mglur5; neuronal polarization ... See more keywords
BDNF specifically expressed in hippocampal neurons is involved in methylmercury neurotoxicity resistance
Sign Up to like & getrecommendations! Published in 2024 at "Environmental Toxicology"
DOI: 10.1002/tox.24174
Abstract: Methylmercury (MeHg) causes selective neuronal damage to cerebrocortical neurons (CCNs) in the central nervous system, but not to hippocampal neurons (HiNs), which are highly vulnerable to neurodegenerative diseases. In our previous study using cultured rat… read more here.
Keywords: neurotoxicity; resistance; hippocampal neurons; specifically expressed ... See more keywords