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   Articles with "hipsc" as a keyword



Bioactivity and miRNome Profiling of Native Extracellular Vesicles in Human Induced Pluripotent Stem Cell‐Cardiomyocyte Differentiation

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recommendations! Published in 2022 at "Advanced Science"

DOI: 10.1002/advs.202104296

Abstract: Extracellular vesicles (EV) are an attractive therapy to boost cardiac regeneration. Nevertheless, identification of native EV and corresponding cell platform(s) suitable for therapeutic application, is still a challenge. Here, EV are isolated from key stages… read more here.

Keywords: cell; cell cardiomyocyte; stem cell; hipsc ... See more keywords

Generation of a Human Induced Pluripotent Stem Cell Line Expressing a Magnetic Resonance Imaging Reporter Gene

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recommendations! Published in 2024 at "Small Methods"

DOI: 10.1002/smtd.202301764

Abstract: The objective of the current study is to develop a new method for tracking transplanted human induced pluripotent stem cells‐derived cardiomyocytes (hiPSC‐CMs) using magnetic resonance imaging (MRI). The CRISPR/dCas9 activation system is employed to overexpress… read more here.

Keywords: hipsc fhcoe; fhc hipsc; hipsc; hipsc cms ... See more keywords

M97 TRANSCRIPTIONAL SIGNATURES OF CHILDHOOD ONSET SCHIZOPHRENIA IN HIPSC-DERIVED NPCS AND NEURONS ARE CONCORDANT WITH SIGNATURES FROM POST MORTEM ADULT BRAINS

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recommendations! Published in 2019 at "European Neuropsychopharmacology"

DOI: 10.1016/j.euroneuro.2017.08.404

Abstract: Background Large-scale Genome Wide Association Studies (GWAS) revealed that Schizophrenia (SZ) risk reflects both rare and common variants. Whereas highly penetrant rare variants have proven well-suited to human induced pluripotent stem cell (hiPSC)-based models, the… read more here.

Keywords: hipsc derived; hipsc; hipsc based; post mortem ... See more keywords

Overexpression of KCNJ2 in induced pluripotent stem cell-derived cardiomyocytes for the assessment of QT-prolonging drugs.

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recommendations! Published in 2017 at "Journal of pharmacological sciences"

DOI: 10.1016/j.jphs.2017.05.004

Abstract: Human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes hold great potentials to predict pro-arrhythmic risks in preclinical cardiac safety screening, although the hiPSC cardiomyocytes exhibit rather immature functional and structural characteristics, including spontaneous activity. Our physiological… read more here.

Keywords: hipsc derived; hipsc; derived cardiomyocytes; pluripotent stem ... See more keywords
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Genomic integrity of human induced pluripotent stem cells across nine studies in the NHLBI NextGen program

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recommendations! Published in 2020 at "Stem cell research"

DOI: 10.1016/j.scr.2020.101803

Abstract: Human induced pluripotent stem cell (hiPSC) lines have previously been generated through the NHLBI sponsored NextGen program at nine individual study sites. Here, we examined the structural integrity of 506 hiPSC lines as determined by… read more here.

Keywords: nextgen program; human induced; hipsc; pluripotent stem ... See more keywords

Establishment of a PRKAG2 cardiac syndrome disease model and mechanism study using human induced pluripotent stem cells.

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recommendations! Published in 2018 at "Journal of molecular and cellular cardiology"

DOI: 10.1016/j.yjmcc.2018.02.007

Abstract: PRKAG2 cardiac syndrome is a distinct form of human cardiomyopathy characterized by cardiac hypertrophy, ventricular pre-excitation and progressive cardiac conduction disorder. However, it remains unclear how mutations in the PRKAG2 gene give rise to such… read more here.

Keywords: prkag2 cardiac; hipsc; disease; cardiac syndrome ... See more keywords

Reference glycan structure libraries of primary human cardiomyocytes and pluripotent stem cell-derived cardiomyocytes reveal cell-type and culture stage-specific glycan phenotypes.

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recommendations! Published in 2020 at "Journal of molecular and cellular cardiology"

DOI: 10.1016/j.yjmcc.2019.12.012

Abstract: Cell surface glycoproteins play critical roles in maintaining cardiac structure and function in health and disease and the glycan-moiety attached to the protein is critical for proper protein folding, stability and signaling (Ajit Varki [1]).… read more here.

Keywords: glycan structure; heart; structure libraries; hipsc ... See more keywords

Aligned Nanofibrous Net Deposited Perpendicularly on Microridges Supports Endothelium Formation and Promotes the Structural Maturation of hiPSC-Derived Cardiomyocytes.

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recommendations! Published in 2023 at "ACS applied materials & interfaces"

DOI: 10.1021/acsami.2c22551

Abstract: Cell alignment widely exists in various in vivo tissues and also plays an essential role in the construction of in vitro models, such as vascular endothelial and myocardial models. Recently, microscale and nanoscale hierarchical topographical… read more here.

Keywords: cell; maturation; endothelium formation; hipsc cms ... See more keywords

Proteomic Approach Using DIA-MS Identifies Morphogenesis-Associated Proteins during Cardiac Differentiation of Human iPS Cells

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recommendations! Published in 2024 at "ACS Omega"

DOI: 10.1021/acsomega.4c06371

Abstract: Human-induced pluripotent stem cell (hiPSC)-derived cardiomyocytes have potential applications in regenerative medicine. The quality by design (QbD) approach enables the efficiency and quality assurance in the manufacturing of hiPSC-derived products. It requires a molecular understanding… read more here.

Keywords: differentiation; cardiac differentiation; proteomic approach; hipsc ... See more keywords

HiPSC-derived cardiomyocyte cultivation and measurement of electrophysiological properties on gelatine/glucose/polypyrrole scaffold

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recommendations! Published in 2024 at "Cardiovascular Research"

DOI: 10.1093/cvr/cvae088.042

Abstract: Type of funding sources: Public grant(s) – EU funding. Main funding source(s): EU Horizon 2020 Framework Programme (H2020) under Grant agreements No. 953138 (EMAPS-Cardio) Cardiotoxicity is one of the main side effects limiting development of… read more here.

Keywords: gelatine glucose; scaffold; hipsc cms; hipsc ... See more keywords

Engineering hiPSC-derived tissue models for advanced amyloidosis research and therapy development

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recommendations! Published in 2024 at "European Heart Journal"

DOI: 10.1093/eurheartj/ehae666.3777

Abstract: Transthyretin (TTR) amyloid cardiomyopathy (ATTR-CM) is a life-threatening disease currently lacking an optimal therapy, stemming from the absence of representative models. Our work aims to stablish for the first time an all-human 3D model of… read more here.

Keywords: tissue models; engineering hipsc; hipsc derived; therapy ... See more keywords