Bioactivity and miRNome Profiling of Native Extracellular Vesicles in Human Induced Pluripotent Stem Cell‐Cardiomyocyte Differentiation
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202104296
Abstract: Extracellular vesicles (EV) are an attractive therapy to boost cardiac regeneration. Nevertheless, identification of native EV and corresponding cell platform(s) suitable for therapeutic application, is still a challenge. Here, EV are isolated from key stages… read more here.
Keywords: cell; cell cardiomyocyte; stem cell; hipsc ... See more keywords
M97 TRANSCRIPTIONAL SIGNATURES OF CHILDHOOD ONSET SCHIZOPHRENIA IN HIPSC-DERIVED NPCS AND NEURONS ARE CONCORDANT WITH SIGNATURES FROM POST MORTEM ADULT BRAINS
Sign Up to like & getrecommendations! Published in 2019 at "European Neuropsychopharmacology"
DOI: 10.1016/j.euroneuro.2017.08.404
Abstract: Background Large-scale Genome Wide Association Studies (GWAS) revealed that Schizophrenia (SZ) risk reflects both rare and common variants. Whereas highly penetrant rare variants have proven well-suited to human induced pluripotent stem cell (hiPSC)-based models, the… read more here.
Keywords: hipsc derived; hipsc; hipsc based; post mortem ... See more keywords
Overexpression of KCNJ2 in induced pluripotent stem cell-derived cardiomyocytes for the assessment of QT-prolonging drugs.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of pharmacological sciences"
DOI: 10.1016/j.jphs.2017.05.004
Abstract: Human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes hold great potentials to predict pro-arrhythmic risks in preclinical cardiac safety screening, although the hiPSC cardiomyocytes exhibit rather immature functional and structural characteristics, including spontaneous activity. Our physiological… read more here.
Keywords: hipsc derived; hipsc; derived cardiomyocytes; pluripotent stem ... See more keywords
Genomic integrity of human induced pluripotent stem cells across nine studies in the NHLBI NextGen program
Sign Up to like & getrecommendations! Published in 2020 at "Stem cell research"
DOI: 10.1016/j.scr.2020.101803
Abstract: Human induced pluripotent stem cell (hiPSC) lines have previously been generated through the NHLBI sponsored NextGen program at nine individual study sites. Here, we examined the structural integrity of 506 hiPSC lines as determined by… read more here.
Keywords: nextgen program; human induced; hipsc; pluripotent stem ... See more keywords
Establishment of a PRKAG2 cardiac syndrome disease model and mechanism study using human induced pluripotent stem cells.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of molecular and cellular cardiology"
DOI: 10.1016/j.yjmcc.2018.02.007
Abstract: PRKAG2 cardiac syndrome is a distinct form of human cardiomyopathy characterized by cardiac hypertrophy, ventricular pre-excitation and progressive cardiac conduction disorder. However, it remains unclear how mutations in the PRKAG2 gene give rise to such… read more here.
Keywords: prkag2 cardiac; hipsc; disease; cardiac syndrome ... See more keywords
Reference glycan structure libraries of primary human cardiomyocytes and pluripotent stem cell-derived cardiomyocytes reveal cell-type and culture stage-specific glycan phenotypes.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of molecular and cellular cardiology"
DOI: 10.1016/j.yjmcc.2019.12.012
Abstract: Cell surface glycoproteins play critical roles in maintaining cardiac structure and function in health and disease and the glycan-moiety attached to the protein is critical for proper protein folding, stability and signaling (Ajit Varki [1]).… read more here.
Keywords: glycan structure; heart; structure libraries; hipsc ... See more keywords
Aligned Nanofibrous Net Deposited Perpendicularly on Microridges Supports Endothelium Formation and Promotes the Structural Maturation of hiPSC-Derived Cardiomyocytes.
Sign Up to like & getrecommendations! Published in 2023 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.2c22551
Abstract: Cell alignment widely exists in various in vivo tissues and also plays an essential role in the construction of in vitro models, such as vascular endothelial and myocardial models. Recently, microscale and nanoscale hierarchical topographical… read more here.
Keywords: cell; maturation; endothelium formation; hipsc cms ... See more keywords
P2572Human iPSC-derived cardiomyocytes preserve murine heart function after myocardial infarction unlike adipose tissue-derived stromal cells
Sign Up to like & getrecommendations! Published in 2019 at "European Heart Journal"
DOI: 10.1093/eurheartj/ehz748.0899
Abstract: Despite progress in pharmacological treatment of myocardial infarction (MI), there is still an immense need for novel therapies for this life-threatening condition. Accordingly, cell-based therapies have been extensively investigated with most studies focusing on mesenchymal… read more here.
Keywords: administration; heart; myocardial infarction; stromal cells ... See more keywords
Practical adoption of state-of-the-art hiPSC-cardiomyocyte differentiation techniques
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DOI: 10.1371/journal.pone.0230001
Abstract: Human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes are a valuable resource for cardiac therapeutic development; however, generation of these cells in large numbers and high purity is a limitation in widespread adoption. Here, design of… read more here.
Keywords: hipsc; adoption; differentiation; hipsc cardiomyocyte ... See more keywords
In vitro methods to ensure absence of residual undifferentiated human induced pluripotent stem cells intermingled in induced nephron progenitor cells
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DOI: 10.1371/journal.pone.0275600
Abstract: Cell therapies using human induced pluripotent stem cell (hiPSC)-derived nephron progenitor cells (NPCs) are expected to ameliorate acute kidney injury (AKI). However, using hiPSC-derived NPCs clinically is a challenge because hiPSCs themselves are tumorigenic. LIN28A,… read more here.
Keywords: pluripotent stem; hipsc derived; hipsc; nephron progenitor ... See more keywords
Effect of Xenogeneic Substances on the Glycan Profiles and Electrophysiological Properties of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes.
Sign Up to like & getrecommendations! Published in 2023 at "International journal of stem cells"
DOI: 10.15283/ijsc22158
Abstract: Background and Objectives Human induced pluripotent stem cell (hiPSC)-derived cardiomyocyte (CM) hold great promise as a cellular source of CM for cardiac function restoration in ischemic heart disease. However, the use of animal-derived xenogeneic substances… read more here.
Keywords: cell; hipsc; glycan profiles; stem ... See more keywords