M97 TRANSCRIPTIONAL SIGNATURES OF CHILDHOOD ONSET SCHIZOPHRENIA IN HIPSC-DERIVED NPCS AND NEURONS ARE CONCORDANT WITH SIGNATURES FROM POST MORTEM ADULT BRAINS
Sign Up to like & getrecommendations! Published in 2019 at "European Neuropsychopharmacology"
DOI: 10.1016/j.euroneuro.2017.08.404
Abstract: Background Large-scale Genome Wide Association Studies (GWAS) revealed that Schizophrenia (SZ) risk reflects both rare and common variants. Whereas highly penetrant rare variants have proven well-suited to human induced pluripotent stem cell (hiPSC)-based models, the… read more here.
Keywords: hipsc derived; hipsc; hipsc based; post mortem ... See more keywords
Astrocyte-enriched feeder layers from cryopreserved cells support differentiation of spontaneously active networks of human iPSC-derived neurons
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Neuroscience Methods"
DOI: 10.1016/j.jneumeth.2017.07.019
Abstract: BACKGROUND Human induced pluripotent stem cell (hiPSC)-derived neuronal cultures are a useful tool for studying the mechanisms of neurological disorders and developing novel therapeutics. While plating hiPSC-derived neuronal progenitors onto glial feeder layers prepared from… read more here.
Keywords: astrocyte enriched; differentiation; hipsc derived; feeder ... See more keywords
Overexpression of KCNJ2 in induced pluripotent stem cell-derived cardiomyocytes for the assessment of QT-prolonging drugs.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of pharmacological sciences"
DOI: 10.1016/j.jphs.2017.05.004
Abstract: Human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes hold great potentials to predict pro-arrhythmic risks in preclinical cardiac safety screening, although the hiPSC cardiomyocytes exhibit rather immature functional and structural characteristics, including spontaneous activity. Our physiological… read more here.
Keywords: hipsc derived; hipsc; derived cardiomyocytes; pluripotent stem ... See more keywords
Assessment of ELISA as endpoint in neuronal cell-based assay for BoNT detection using hiPSC derived neurons.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of pharmacological and toxicological methods"
DOI: 10.1016/j.vascn.2017.04.013
Abstract: INTRODUCTION Botulinum neurotoxins (BoNTs), the causative agents of botulism, are widely used as powerful bio-pharmaceuticals to treat neuro-muscular disorders. Due to the high potency and potential lethality of BoNTs, careful monitoring of the biologic activity… read more here.
Keywords: detection; derived neurons; cell based; hipsc derived ... See more keywords
Characterization of human iPSC-derived sensory neurons and their functional assessment using multi electrode array
Sign Up to like & getrecommendations! Published in 2024 at "Scientific Reports"
DOI: 10.1038/s41598-024-55602-8
Abstract: Sensory neurons are afferent neurons in sensory systems that convert stimuli and transmit information to the central nervous system as electrical signals. Primary afferent neurons that are affected by non-noxious and noxious stimuli are present… read more here.
Keywords: sensory neurons; hipsc derived; derived sensory; electrode array ... See more keywords
Engineering hiPSC-derived tissue models for advanced amyloidosis research and therapy development
Sign Up to like & getrecommendations! Published in 2024 at "European Heart Journal"
DOI: 10.1093/eurheartj/ehae666.3777
Abstract: Transthyretin (TTR) amyloid cardiomyopathy (ATTR-CM) is a life-threatening disease currently lacking an optimal therapy, stemming from the absence of representative models. Our work aims to stablish for the first time an all-human 3D model of… read more here.
Keywords: tissue models; engineering hipsc; hipsc derived; therapy ... See more keywords
Abstract 145: Unraveling SMARCB1 depletion in hiPSC-derived neural crest cells: Implications for ATRT cell of origin
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.am2024-145
Abstract: Atypical teratoid rhabdoid tumors (ATRTs) are highly aggressive pediatric brain cancers that lack standardized treatment regimens and are associated with poor prognoses. Despite being driven by biallelic inactivation of a single gene, SMARCB1, ATRTs exhibit… read more here.
Keywords: hipsc derived; crest; crest cells; cell ... See more keywords
Abstract 4366193: Overexpression of Connexin-43 Improves Electrical Conduction between hiPSC-derived Cardiomyocytes
Sign Up to like & getrecommendations! Published in 2025 at "Circulation"
DOI: 10.1161/circ.152.suppl_3.4366193
Abstract: Introduction: Therapy implanting cardiomyocytes (CMs) derived from human induced pluripotent stem cells (hiPSCs) is a promising technique to treat damaged myocardium. However, electrophysiological compatibility between the implanted tissue graft and the host heart remains a… read more here.
Keywords: cx43; hipsc derived; culture; electrical conduction ... See more keywords
Directed Differentiation of Human Induced Pluripotent Stem Cells to Heart Valve Cells
Sign Up to like & getrecommendations! Published in 2024 at "Circulation"
DOI: 10.1161/circulationaha.123.065143
Abstract: BACKGROUND: A main obstacle in current valvular heart disease research is the lack of high-quality homogeneous functional heart valve cells. Human induced pluripotent stem cells (hiPSCs)-derived heart valve cells may help with this dilemma. However,… read more here.
Keywords: hipsc derived; heart valve; heart; derived valve ... See more keywords
From inserts to chips: microfluidic culture and 3D astrocyte co-culture drive functional and transcriptomic changes in hiPSC-derived endothelial cells
Sign Up to like & getrecommendations! Published in 2025 at "Fluids and Barriers of the CNS"
DOI: 10.1186/s12987-025-00672-7
Abstract: The blood-brain barrier (BBB) exhibits a hurdle for drug delivery and development. In addition, the dysfunction of the BBB has been seen in several neurodegenerative diseases, although the mechanisms remain poorly understood. Thus, improved models… read more here.
Keywords: hipsc derived; culture; cell; akita plate ... See more keywords
In vitro methods to ensure absence of residual undifferentiated human induced pluripotent stem cells intermingled in induced nephron progenitor cells
Sign Up to like & getrecommendations! Published in 2022 at "PLOS ONE"
DOI: 10.1371/journal.pone.0275600
Abstract: Cell therapies using human induced pluripotent stem cell (hiPSC)-derived nephron progenitor cells (NPCs) are expected to ameliorate acute kidney injury (AKI). However, using hiPSC-derived NPCs clinically is a challenge because hiPSCs themselves are tumorigenic. LIN28A,… read more here.
Keywords: pluripotent stem; hipsc derived; hipsc; nephron progenitor ... See more keywords