Generation of a hiPSC line ZZUNEUi007-A from a patient with hypertrophic cardiomyopathy caused by mutation in MYH7.
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DOI: 10.1016/j.scr.2020.101699
Abstract: Hypertrophic cardiomyopathy (HCM) is the most common monogenic cardiovascular disorder. In this study, we generated human induced pluripotent stem cells (iPSC) ZZUNEUi007-A from dermal fibroblasts of an HCM patient with the p. R663H (c. 1988… read more here.
Keywords: mutation myh7; hypertrophic cardiomyopathy; hipsc line;
Generation of a hiPSC line ZZUNEUi012-A from a healthy female individual.
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DOI: 10.1016/j.scr.2020.102143
Abstract: Induced pluripotent stem cells (iPSCs) have differentiation potential into different somatic cell types in vitro and are a useful tool to investigate pathomechanistic and cellular processes. In this study, we generated human induced pluripotent stem… read more here.
Keywords: healthy female; female individual; zzuneui012; generation hipsc ... See more keywords
Generation of a homozygous ARHGAP11B knockout hiPSC line by CRISPR/Cas9 system.
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DOI: 10.1016/j.scr.2022.102764
Abstract: The human specific gene ARHGAP11B is preferentially expressed in neural progenitors of fetal neocortex and plays a key role in the evolutionary expansion of the neocortex. Here, we generated a homozygous ARHGAP11B knockout human induced… read more here.
Keywords: crispr cas9; homozygous arhgap11b; line; hipsc line ... See more keywords