Genomic integrity of human induced pluripotent stem cells across nine studies in the NHLBI NextGen program
Sign Up to like & getrecommendations! Published in 2020 at "Stem cell research"
DOI: 10.1016/j.scr.2020.101803
Abstract: Human induced pluripotent stem cell (hiPSC) lines have previously been generated through the NHLBI sponsored NextGen program at nine individual study sites. Here, we examined the structural integrity of 506 hiPSC lines as determined by… read more here.
Keywords: nextgen program; human induced; hipsc; pluripotent stem ... See more keywords
Generation of two hiPSC lines (MHHi016-A, MHHi016-B) from a primary ciliary dyskinesia patient carrying a homozygous 5 bp duplication (c.248_252dup (p.Gly85Cysfs*11)) in exon 1 of the CCNO gene.
Sign Up to like & getrecommendations! Published in 2020 at "Stem cell research"
DOI: 10.1016/j.scr.2020.101850
Abstract: Cyclin O (CCNO) is involved in cell cycle regulation and mutations of CCNO are linked to the rare genetic disease primary ciliary dyskinesia (PCD). Mutations in CCNO are associated with reduced cilia number and cilia… read more here.
Keywords: primary ciliary; ciliary dyskinesia; patient carrying; exon ccno ... See more keywords
CXCL4/PF4 is a predictive biomarker of cardiac differentiation potential of human induced pluripotent stem cells
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-40915-w
Abstract: Selection of human induced pluripotent stem cell (hiPSC) lines with high cardiac differentiation potential is important for regenerative therapy and drug screening. We aimed to identify biomarkers for predicting cardiac differentiation potential of hiPSC lines… read more here.
Keywords: biomarker; human induced; differentiation potential; hipsc lines ... See more keywords