Prohibitin participates in the HIRA complex to promote cell metastasis in breast cancer cell lines
Sign Up to like & getrecommendations! Published in 2020 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.12966
Abstract: Prohibitin (PHB) is a highly conserved, ubiquitously expressed, multifunctional protein with a well‐characterized function as a chaperone‐stabilizing mitochondrial proteins. Recently it was reported that nuclear PHB participates in HIRA chaperone complexes and regulates downstream gene… read more here.
Keywords: phb; breast cancer; cancer; cell ... See more keywords
PHB Associates with the HIRA Complex to Control an Epigenetic-Metabolic Circuit in Human ESCs.
Sign Up to like & getrecommendations! Published in 2017 at "Cell stem cell"
DOI: 10.1016/j.stem.2016.11.002
Abstract: The chromatin landscape and cellular metabolism both contribute to cell fate determination, but their interplay remains poorly understood. Using genome-wide siRNA screening, we have identified prohibitin (PHB) as an essential factor in self-renewal of human embryonic… read more here.
Keywords: control; metabolic circuit; phb; hira complex ... See more keywords