Molecular dynamic and pharmacological studies on protein‐engineered hirudin variants of Hirudinaria manillensis and Hirudo medicinalis
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DOI: 10.1111/bph.15816
Abstract: Hirudin variants are the most powerful thrombin inhibitors discovered to date, with a lower risk of bleeding than heparin. For anticoagulation, the C‐termini of hirudin variants bind to the exocite I of thrombin. Anticoagulant effects… read more here.
Keywords: hirudin variants; studies protein; molecular dynamic; pharmacological studies ... See more keywords