Biological Evaluation of Selected Flavonoids as Inhibitors of MNKs Targeting Acute Myeloid Leukemia.
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DOI: 10.1021/acs.jnatprod.0c00516
Abstract: Excessive eIF4E phosphorylation by mitogen-activated protein kinase (MAPK)-interacting kinases 1 and 2 (MNK1 and MNK2; collectively, MNKs) has been associated with oncogenesis. The overexpression of eIF4E in acute myeloid leukemia (AML) is related to cancer… read more here.
Keywords: myeloid leukemia; hispidulin luteolin; eif4e phosphorylation; acute myeloid ... See more keywords