Hispolon: A natural polyphenol and emerging cancer killer by multiple cellular signaling pathways
Sign Up to like & getrecommendations! Published in 2020 at "Environmental Research"
DOI: 10.1016/j.envres.2020.110017
Abstract: Abstract Nature as an infinite treasure of chemotypes and pharmacophores will continue to play an imperative role in the drug discovery. Natural products (NPs) such as plant and fungal metabolites have emerged as leads in… read more here.
Keywords: hispolon; signaling pathways; cellular signaling; drug ... See more keywords
Toxicity and Antigenotoxic Effect of Hispolon Derivatives: Role of Structure in Modulating Cellular Redox State and Thioredoxin Reductase
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DOI: 10.1021/acsomega.8b00415
Abstract: Hispolon (HS), a bioactive polyphenol, and its derivatives such as hispolon monomethyl ether (HME), hispolon pyrazole (HP), and hispolon monomethyl ether pyrazole (HMEP) were evaluated for comparative toxicity and antigenotoxic effects. The stability of HS… read more here.
Keywords: hispolon; thioredoxin reductase; hme; toxicity ... See more keywords
Hispolon Cyclodextrin Complexes and Their Inclusion in Liposomes for Enhanced Delivery in Melanoma Cell Lines
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232214487
Abstract: Hispolon, a phenolic pigment isolated from the mushroom species Phellinus linteus, has been investigated for anti-inflammatory, antioxidant, and anticancer properties; however, low solubility and poor bioavailability have limited its potential clinical translation. In this study,… read more here.
Keywords: hispolon; melanoma cell; hsc; inclusion ... See more keywords
Immunomodulatory Effect of Hispolon on LPS-Induced RAW264.7 Cells and Mitogen/Alloantigen-Stimulated Spleen Lymphocytes of Mice
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics14071423
Abstract: Hispolon is a potent anticancer, anti-inflammatory, antioxidant, and antidiabetic agent isolated from Phellinus linteus, an oriental medicinal mushroom. However, the immunomodulatory mechanisms by which hispolon affects macrophages and lymphocytes remain poorly characterized. We investigated the… read more here.
Keywords: raw264 cells; mitogen alloantigen; hispolon; lps induced ... See more keywords
Protective role of hispolon pyrazole and hispolon monomethyl ether pyrazole in electromagnetic radiation-induced behavioral, neurochemical, oxidative, and histological changes in rats
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Herbmed Pharmacology"
DOI: 10.34172/jhp.2023.32
Abstract: Introduction: Radiofrequency electromagnetic radiation (RF-EMR) from mobile phones was reported to cause neurological damage. Hispolon pyrazole (HP) and hispolon monomethyl ether pyrazole (HMEP) were tested for their RF-EMR protection in rats. Methods: Juvenile Wistar albino… read more here.
Keywords: hispolon; hispolon monomethyl; hispolon pyrazole; pyrazole hispolon ... See more keywords