Brain histamine depletion enhances the behavioural sequences complexity of mice tested in the open-field: Partial reversal effect of the dopamine D2/D3 antagonist sulpiride
Sign Up to like & getrecommendations! Published in 2017 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2016.11.007
Abstract: &NA; Markers of histaminergic dysregulation were found in several neuropsychiatric disorders characterized by repetitive behaviours, thoughts and stereotypies. We analysed the effect of acute histamine depletion by means of i. c.v. injections of alphaâfluoromethylhistidine, a… read more here.
Keywords: open field; histamine depletion; histamine; complexity ... See more keywords
Chronic brain histamine depletion in adult mice induced depression-like behaviours and impaired sleep-wake cycle
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DOI: 10.1016/j.neuropharm.2020.108179
Abstract: Histamine acts as a neurotransmitter to regulate various physiological processes. Brain histamine is synthesized from an essential amino acid histidine in a reaction catalysed by histidine decarboxylase (Hdc). Hdc-positive neurons exist mainly in the tuberomammillary… read more here.
Keywords: brain histamine; histamine depletion; histamine; mice ... See more keywords