Calcium/calmodulin-dependent regulation of Rac GTPases and Akt in histamine-induced chemotaxis of mast cells.
Sign Up to like & getrecommendations! Published in 2021 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2021.109973
Abstract: Histamine induces chemotaxis of mast cells through the histamine H4 receptor. This involves the activation of small GTPases, Rac1 and Rac2, downstream of phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K). Activation of the H4 receptor also results in phospholipase… read more here.
Keywords: calcium; mast cells; histamine induced; rac ... See more keywords
Pharmacological screening of Acalypha indica L.: Possible role in the treatment of asthma.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2022.115093
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Acalypha indica Linn (Euphorbiaceae), a popular traditional medicine, is an erect herb found throughout various parts of India. In Ayurveda, Acalypha indica was commonly used in asthma and allergy. However, no attempts were… read more here.
Keywords: treatment asthma; acalypha indica; clonidine; acalypha ... See more keywords
Anti-inflammatory and bronchodilatory constituents of leaf extracts of Anacardium occidentale L. in animal models.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of integrative medicine"
DOI: 10.1016/j.joim.2017.12.009
Abstract: OBJECTIVE Anacardium occidentale L. leaf is useful in the treatment of inflammation and asthma, but the bioactive constituents responsible for these activities have not been characterized. Therefore, this study was aimed at identifying the bioactive… read more here.
Keywords: anti inflammatory; bronchodilatory anti; bronchoconstriction; bronchodilatory ... See more keywords
Paclitaxel and Urolithin A Prevent Histamine-Induced Neurovascular Breakdown Alike, in an Ex Vivo Rat Eye Model.
Sign Up to like & getrecommendations! Published in 2022 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.1c00692
Abstract: Neurovascular eye problems are better prevented than managed or treated. Despite growing concern of occurrence in aging populations and development secondary to diseases such as diabetes and hypertension, we currently have very few options to… read more here.
Keywords: eye; vivo rat; rat eye; eye model ... See more keywords
Histamine induced high mobility group box-1 release from vascular endothelial cells through H1 receptor
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.930683
Abstract: Background Systemic allergic reaction is characterized by vasodilation and vascular leakage, which causes a rapid, precipitous and sustained decrease in arterial blood pressure with a concomitant decrease of cardiac output. Histamine is a major mediator… read more here.
Keywords: endothelial cells; release; histamine; hmgb1 ... See more keywords
TRPV1 and TRPA1 Channels Are Both Involved Downstream of Histamine-Induced Itch
Sign Up to like & getrecommendations! Published in 2021 at "Biomolecules"
DOI: 10.3390/biom11081166
Abstract: Two histamine receptor subtypes (HR), namely H1R and H4R, are involved in the transmission of histamine-induced itch as key components. Although exact downstream signaling mechanisms are still elusive, transient receptor potential (TRP) ion channels play… read more here.
Keywords: induced itch; histamine induced; trpv1 trpa1;