Metoprine, a histamine N-methyltransferase inhibitor, attenuates methamphetamine-induced hyperlocomotion via activation of histaminergic neurotransmission in mice
Sign Up to like & getrecommendations! Published in 2021 at "Pharmacology Biochemistry and Behavior"
DOI: 10.1016/j.pbb.2021.173257
Abstract: Metoprine increases the content of histamine in brain by inhibiting histamine N-methyltransferase (HMT), a centrally acting histamine degrading enzyme. We present data demonstrating that pretreatment with metoprine attenuates the hyperlocomotive effects of METH in mice… read more here.
Keywords: induced hyperlocomotion; metoprine; histamine; mice ... See more keywords
Histamine N-methyltransferase regulates aggression and the sleep-wake cycle
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-16019-8
Abstract: Histamine is a neurotransmitter that regulates diverse physiological functions including the sleep-wake cycle. Recent studies have reported that histaminergic dysfunction in the brain is associated with neuropsychiatric disorders. Histamine N-methyltransferase (HNMT) is an enzyme expressed… read more here.
Keywords: sleep wake; wake cycle; histamine methyltransferase; histamine ... See more keywords