Molecular Modelling Approaches for the Analysis of Histamine Receptors and Their Interaction with Ligands.
Sign Up to like & getrecommendations! Published in 2017 at "Handbook of experimental pharmacology"
DOI: 10.1007/164_2016_113
Abstract: Several experimental techniques to analyse histamine receptors are available, e.g. pharmacological characterisation of known or new compounds by different types of assays or mutagenesis studies. To obtain insights into the histamine receptors on a molecular… read more here.
Keywords: dynamic simulations; modelling approaches; histamine receptors; molecular modelling ... See more keywords
The Role of the Central Histaminergic System in Behavioral State Control.
Sign Up to like & getrecommendations! Published in 2021 at "Current topics in behavioral neurosciences"
DOI: 10.1007/7854_2021_263
Abstract: Histamine is a small monoamine signaling molecule that plays a role in many peripheral and central physiological processes, including the regulation of wakefulness. The tuberomammillary nucleus is the sole neuronal source of histamine in the… read more here.
Keywords: system; behavioral state; histamine; role ... See more keywords
Contractile effects of dexmedetomidine in the human heart
Sign Up to like & getrecommendations! Published in 2025 at "Naunyn-Schmiedeberg's Archives of Pharmacology"
DOI: 10.1007/s00210-025-04192-x
Abstract: Dexmedetomidine is an approved drug that is chemically related to clonidine. Dexmedetomidine is used to induce sedation and anxiolysis. These therapeutic effects of dexmedetomidine are explained by its agonistic action on brain α2-adrenoceptors. We tested… read more here.
Keywords: force contraction; heart; dexmedetomidine; histamine receptors ... See more keywords
Histamine 2 receptors in cardiovascular biology: a friend for the heart.
Sign Up to like & getrecommendations! Published in 2021 at "Drug discovery today"
DOI: 10.1016/j.drudis.2021.08.008
Abstract: Undermining new mediators involved in the development and progression of cardiovascular diseases (CVDs) is vital for better disease management. Existing studies implicate a crucial role for inflammation and inflammatory cells, particularly mast cells, in cardiac… read more here.
Keywords: heart; cardiovascular biology; biology; receptors cardiovascular ... See more keywords
Structural basis of ligand recognition and activation of the histamine receptor family
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DOI: 10.1038/s41467-024-52585-y
Abstract: Histamine is a biogenic amine that is critical in various physiological and pathophysiological processes, including but not limited to allergic reactions, wakefulness, gastric acid secretion and neurotransmission. Here, we determine 9 cryo-electron microscopy (cryo-EM) structures… read more here.
Keywords: ligand recognition; ligand; structural basis; histamine ... See more keywords
Histamine and its H1 receptors in the ventral pallidum mediate formalin-induced pain-related behaviors through this region and spinal cord opioid receptors.
Sign Up to like & getrecommendations! Published in 2023 at "Behavioural pharmacology"
DOI: 10.1097/fbp.0000000000000724
Abstract: Many structures of the central nervous system recruit different neurotransmitters in pain processing. This study focused on the contribution of histamine and its H1 receptors in the ventral pallidum (VP) in mediating pain-triggered behaviors. Intra-VP… read more here.
Keywords: ventral pallidum; histamine receptors; opioid receptors; receptors ventral ... See more keywords
Histamine upregulates the expression of histamine receptors and increases the neuroprotective effect of astrocytes
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Neuroinflammation"
DOI: 10.1186/s12974-018-1068-x
Abstract: BackgroundAstrocytes have attracted increasing attention over recent decades for their role in neuroinflammation. Histamine, a major aminergic brain neurotransmitter, has an important influence on the main activities of astrocytes, such as ion homeostasis, energy metabolism,… read more here.
Keywords: h2r h3r; histamine; h1r h2r; histamine receptors ... See more keywords
Correlation of Histamine Receptors and Adrenergic Receptor in Broilers Appetite
Sign Up to like & getrecommendations! Published in 2021 at "archives of razi institute"
DOI: 10.22092/ari.2021.354450.1638
Abstract: The current study was conducted to investigate the interaction between the central adrenergic and histaminergic systems on the broiler chicks feed intake. In the first experiment, the control solution, 10 nmol of prazosin (an α1-receptor… read more here.
Keywords: adrenergic receptor; histamine receptors; injection; receptor ... See more keywords
Histamine 2 Receptor Agonism and Histamine 4 Receptor Antagonism Ameliorate Inflammation in a Model of Psoriasis.
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DOI: 10.2340/00015555-3674
Abstract: Psoriasis is a chronic inflammatory skin disorder characterized by hyperproliferative keratinocytes and immune cell infiltration into the skin, often accompanied by itch. Histamine, acting via histamine 1-4 receptors, is known to modulate immune responses in… read more here.
Keywords: inflammation; histamine; histamine receptors; psoriasis ... See more keywords
The Role of Histamine and Histamine Receptors in Mast Cell-Mediated Allergy and Inflammation: The Hunt for New Therapeutic Targets
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2018.01873
Abstract: Histamine and its receptors (H1R–H4R) play a crucial and significant role in the development of various allergic diseases. Mast cells are multifunctional bone marrow-derived tissue-dwelling cells that are the major producer of histamine in the… read more here.
Keywords: allergic diseases; h1r h4r; therapeutic targets; histamine ... See more keywords
Pharmacological Characterization of 5-Substituted 1-[(2,3-dihydro-1-benzofuran-2-yl)methyl]piperazines: Novel Antagonists for the Histamine H3 and H4 Receptors with Anti-inflammatory Potential
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2017.00825
Abstract: The histamine receptors (HRs) are traditional G protein-coupled receptors of extensive therapeutic interest. Recently, H3R and H4R subtypes have been targeted in drug discovery projects for inflammation, asthma, pain, cancer, Parkinson’s, and Alzheimer’s diseases, which… read more here.
Keywords: anti inflammatory; benzofuran methyl; dihydro benzofuran; histamine receptors ... See more keywords