Ultrastructural damage in Streptococcus mutans incubated with saliva and histatin 5.
Sign Up to like & getrecommendations! Published in 2018 at "Archives of oral biology"
DOI: 10.1016/j.archoralbio.2018.01.004
Abstract: OBJECTIVE To study the ultrastructural alterations induced in Streptococcus mutans (ATCC 25175) incubated with saliva, saliva plus histatin 5 and histatin 5. METHODS S. mutans incubated with saliva histatin 5 or a combination of both… read more here.
Keywords: saliva histatin; saliva; incubated saliva; histatin ... See more keywords
Salivary Antimicrobial Peptide Histatin-5 Does Not Display Zn(II)-Dependent or -Independent Activity against Streptococci
Sign Up to like & getrecommendations! Published in 2023 at "ACS Infectious Diseases"
DOI: 10.1021/acsinfecdis.2c00578
Abstract: Histatin-5 (Hst5) is a member of the histatin superfamily of cationic, His-rich, Zn(II)-binding peptides in human saliva. Hst5 displays antimicrobial activity against fungal and bacterial pathogens, often in a Zn(II)-dependent manner. In contrast, here we… read more here.
Keywords: salivary antimicrobial; antimicrobial peptide; histatin; activity ... See more keywords
Whole-Genome Approach to Understanding the Mechanism of Action of a Histatin 5-Derived Peptide
Sign Up to like & getrecommendations! Published in 2019 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.01698-19
Abstract: The incidence of opportunistic fungal infections that threaten immunocompromised patients, along with the limited arsenal of antifungal drugs, calls for renewed efforts to develop novel antifungal therapies. Antimicrobial peptides have garnered interest as potential therapeutics.… read more here.
Keywords: histatin; km29; activity; mechanism action ... See more keywords
Long-Term Post-COVID-19 Associated Oral Inflammatory Sequelae
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2022.831744
Abstract: The oral cavity remains an underappreciated site for SARS-CoV-2 infection despite the myriad oral conditions observed in COVID-19 patients. Recently, replicating SARS-CoV-2 was found inside salivary epithelial cells resulting in inflammation and atrophy of salivary… read more here.
Keywords: sars cov; covid; histatin; long term ... See more keywords
Human Salivary Histatin-1 Attenuates Osteoarthritis through Promoting M1/M2 Macrophage Transition
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics15041272
Abstract: Osteoarthritis (OA) is an inflammation-driven degenerative joint disease. Human salivary peptide histatin-1 (Hst1) shows pro-healing and immunomodulatory properties. but its role in OA treatment is not fully understood. In this study, we investigated the efficacy… read more here.
Keywords: human salivary; macrophage; hst1; histatin ... See more keywords