ADAM17 is the main sheddase for the generation of human triggering receptor expressed in myeloid cells (hTREM2) ectodomain and cleaves TREM2 after Histidine 157
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DOI: 10.1016/j.neulet.2017.09.034
Abstract: Triggering receptor expressed in myeloid cells (TREM2) is a member of the immunoglobulin superfamily and is expressed in macrophages, dendritic cells, microglia, and osteoclasts. TREM2 plays a role in phagocytosis, regulates release of cytokine, contributes… read more here.
Keywords: expressed myeloid; histidine 157; myeloid cells; receptor expressed ... See more keywords