Discovery of the Lead Molecules Targeting the First Step of the Histidine Biosynthesis Pathway of Acinetobacter baumannii
Sign Up to like & getrecommendations! Published in 2022 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.1c01421
Abstract: Acinetobacter baumannii is a multidrug-resistant, opportunistic, nosocomial pathogen for which a new line of treatments is desperately needed. We have targeted the enzyme of the first step of the histidine biosynthesis pathway, viz., ATP-phosphoribosyltransferase (ATP-PRT).… read more here.
Keywords: step histidine; histidine biosynthesis; first step; acinetobacter baumannii ... See more keywords
Disruption of De Novo Histidine Biosynthesis of Mycobacterium tuberculosis Affects the Depletion of the Pathogen.
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DOI: 10.1021/acsinfecdis.5c00393
Abstract: Mycobacterium tuberculosis (Mtb), the causative agent of human tuberculosis (TB), employs its de novo histidine (His) biosynthesis to escape host-inflicted His starvation. This makes the enzymes involved in this biosynthetic pathway promising anti-TB drug targets.… read more here.
Keywords: histidine biosynthesis; novo histidine; mycobacterium tuberculosis; tuberculosis ... See more keywords
MIG1 as a positive regulator for the histidine biosynthesis pathway and as a global regulator in thermotolerant yeast Kluyveromyces marxianus
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DOI: 10.1038/s41598-019-46411-5
Abstract: Kmmig1 as a disrupted mutant of MIG1 encoding a regulator for glucose repression in Kluyveromyces marxianus exhibits a histidine-auxotrophic phenotype. Genome-wide expression analysis revealed that only HIS4 in seven HIS genes for histidine biosynthesis was… read more here.
Keywords: kluyveromyces marxianus; regulator; histidine biosynthesis; global regulator ... See more keywords