Synthesis of histidine kinase inhibitors and their biological properties
Sign Up to like & getrecommendations! Published in 2019 at "Medicinal Research Reviews"
DOI: 10.1002/med.21651
Abstract: Infections caused by multidrug‐resistant bacteria represent a significant and ever‐increasing cause of morbidity and mortality. There is thus an urgent need to develop efficient and well‐tolerated antibacterials targeting unique cellular processes. Numerous studies have led… read more here.
Keywords: kinase inhibitors; histidine kinase; inhibitors biological; kinase ... See more keywords
Characterization of five CHASE-containing histidine kinase receptors from Populus × canadensis cv. Robusta sensing isoprenoid and aromatic cytokinins
Sign Up to like & getrecommendations! Published in 2019 at "Planta"
DOI: 10.1007/s00425-019-03297-x
Abstract: Five poplar CHASE-containing histidine kinase receptors bind cytokinins and display kinase activities. Both endogenous isoprenoid and aromatic cytokinins bind to the receptors in live cell assays. Cytokinins are phytohormones that play key roles in various… read more here.
Keywords: containing histidine; histidine kinase; kinase; chase containing ... See more keywords
Oligomeric states in sodium ion-dependent regulation of cyanobacterial histidine kinase-2
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DOI: 10.1007/s00709-017-1196-7
Abstract: Two-component signal transduction systems (TCSs) consist of sensor histidine kinases and response regulators. TCSs mediate adaptation to environmental changes in bacteria, plants, fungi and protists. Histidine kinase 2 (Hik2) is a sensor histidine kinase found… read more here.
Keywords: sodium ion; histidine kinase; oligomeric states; kinase ... See more keywords
Structure-Based Design of Versatile Biosensors for Small Molecules Based on the PAS Domain of a Thermophilic Histidine Kinase.
Sign Up to like & getrecommendations! Published in 2018 at "ACS synthetic biology"
DOI: 10.1021/acssynbio.8b00348
Abstract: The development of biosensors for in vitro quantification of small molecules such as metabolites or man-made chemicals is still a major challenge. Here we show that engineered variants of the sensory PAS domain of the… read more here.
Keywords: pas domain; histidine kinase; small molecules; structure based ... See more keywords
Sequential conformational transitions and α-helical supercoiling regulate a sensor histidine kinase
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/s41467-017-00300-5
Abstract: Sensor histidine kinases are central to sensing in bacteria and in plants. They usually contain sensor, linker, and kinase modules and the structure of many of these components is known. However, it is unclear how… read more here.
Keywords: histidine kinase; histidine; kinase; sensor histidine ... See more keywords
Transcriptomic profiling of Alternaria longipes invasion in tobacco reveals pathogenesis regulated by AlHK1, a group III histidine kinase
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-16401-6
Abstract: Tobacco brown spot, caused by Alternaria species, is a devastating tobacco disease. To explore the role of a group III histidine kinase (AlHK1) on A. longipes pathogenesis, the invasion progress of A. longipes was monitored.… read more here.
Keywords: tobacco; histidine kinase; invasion; group iii ... See more keywords
Insights into the structure and function of the histidine kinase ComP from Bacillus amyloliquefaciens based on molecular modeling
Sign Up to like & getrecommendations! Published in 2022 at "Bioscience Reports"
DOI: 10.1042/bsr20220352
Abstract: Abstract The ComPA two-component signal transduction system (TCS) is essential in Bacillus spp. However, the molecular mechanism of the histidine kinase ComP remains unclear. Here, we predicted the structure of ComP from Bacillus amyloliquefaciens Q-426… read more here.
Keywords: kinase; kinase comp; histidine kinase; bacillus ... See more keywords
Protein design-scapes generated by microfluidic DNA assembly elucidate domain coupling in the bacterial histidine kinase CpxA
Sign Up to like & getrecommendations! Published in 2021 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2017719118
Abstract: Significance DNA variant libraries allow unbiased analysis of sequence–function relationships. However, exhaustive combinatorial assemblies of even a modest number of parts produce libraries too large to practically screen. Library size can be reduced by manually… read more here.
Keywords: cpxa; histidine kinase; dna; sequence ... See more keywords
MifS, a DctB family histidine kinase, is a specific regulator of α-ketoglutarate response in Pseudomonas aeruginosa PAO1.
Sign Up to like & getrecommendations! Published in 2020 at "Microbiology"
DOI: 10.1099/mic.0.000943
Abstract: The C5-dicarboxylate α-ketoglutarate (α-KG) is a preferred nutrient source for the opportunistic pathogen Pseudomonas aeruginosa. However, very little is known about how P. aeruginosa detects and responds to α-KG in the environment. Our laboratory has… read more here.
Keywords: histidine kinase; histidine; dctb family; family histidine ... See more keywords
Conformation control of the histidine kinase BceS of Bacillus subtilis by its cognate ABC‐transporter facilitates need‐based activation of antibiotic resistance
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Microbiology"
DOI: 10.1111/mmi.14607
Abstract: Bacteria closely control gene expression to ensure optimal physiological responses to their environment. Such careful gene expression can minimize the fitness cost associated with antibiotic resistance. We previously described a novel regulatory logic in Bacillus… read more here.
Keywords: histidine kinase; abc transporter; kinase; antibiotic resistance ... See more keywords
Molecular insights into Escherichia coli Cpx envelope stress response activation by the sensor lipoprotein NlpE
Sign Up to like & getrecommendations! Published in 2023 at "Molecular Microbiology"
DOI: 10.1111/mmi.15054
Abstract: Bacterial two‐component signal transduction systems provide sensory inputs for appropriately adapting gene expression. These systems rely on a histidine kinase that phosphorylates a response regulator which alters gene expression. Several two‐component systems include additional sensory… read more here.
Keywords: cpx; escherichia coli; histidine kinase; lipoprotein nlpe ... See more keywords