A high‐efficient strategy for combinatorial engineering paralogous gene family: A case study on histidine kinases in Clostridium
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DOI: 10.1002/bit.27796
Abstract: Microorganisms harbor bulks of functionally similar or undefined genes, which belong to paralogous gene family. There is a necessity of exploring combinatorial or interactive functions of these genes, but conventional loss‐of‐function strategy with one‐by‐one rounds… read more here.
Keywords: gene family; histidine kinases; paralogous gene; strategy ... See more keywords
Sequential conformational transitions and α-helical supercoiling regulate a sensor histidine kinase
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DOI: 10.1038/s41467-017-00300-5
Abstract: Sensor histidine kinases are central to sensing in bacteria and in plants. They usually contain sensor, linker, and kinase modules and the structure of many of these components is known. However, it is unclear how… read more here.
Keywords: histidine kinase; histidine; kinase; sensor histidine ... See more keywords
Diversity and Evolution of Sensor Histidine Kinases in Eukaryotes
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DOI: 10.1093/gbe/evy213
Abstract: Abstract Histidine kinases (HKs) are primary sensor proteins that act in cell signaling pathways generically referred to as “two-component systems” (TCSs). TCSs are among the most widely distributed transduction systems used by both prokaryotic and… read more here.
Keywords: sensor; diversity evolution; evolution; histidine kinases ... See more keywords
Three Orphan Histidine Kinases Inhibit Clostridioides difficile Sporulation
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DOI: 10.1128/jb.00106-22
Abstract: The formation of inactive spores is critical for the long-term survival of the gastrointestinal pathogen Clostridioides difficile. The onset of sporulation is controlled by the master regulator of sporulation, Spo0A, which is activated by phosphorylation.… read more here.
Keywords: sporulation; histidine kinases; phosphorylation; histidine ... See more keywords
What do archaeal and eukaryotic histidine kinases sense?
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DOI: 10.12688/f1000research.20094.1
Abstract: Signal transduction systems configured around a core phosphotransfer step between a histidine kinase and a cognate response regulator protein occur in organisms from all domains of life. These systems, termed two-component systems, constitute the majority… read more here.
Keywords: eukaryotic histidine; archaeal eukaryotic; histidine kinases; component systems ... See more keywords