The type II histidine triad protein HtpsC facilitates invasion of epithelial cells by highly virulent Streptococcus suis serotype 2.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of microbiology"
DOI: 10.1007/s12275-021-1129-1
Abstract: Streptococcus suis serotype 2 (S. suis 2) is an important zoonotic pathogen that presents a significant threat both to pigs and to workers in the pork industry. The initial steps of S. suis 2 pathogenesis… read more here.
Keywords: histidine triad; epithelial cells; type histidine; streptococcus suis ... See more keywords
Plasmodium falciparum histidine triad protein and calmodulin modulates calcium homeostasis and intracellular proteolysis.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.06.067
Abstract: Calcium signaling has an essential role in fundamental processes of Plasmodium life cycle, including migration, cell invasion and parasite development. Two important players in calcium homeostasis, the Histidine Triad (HIT) protein that is implicated in… read more here.
Keywords: calcium; histidine triad; calcium homeostasis;
Biophysical Characterization and Thermal Stability of Pneumococcal Histidine Triad Protein D in the Presence of Zinc and Manganese.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2017.06.003
Abstract: The pneumococcal histidine triad protein D (PhtD) is believed to play a central role in pneumococcal metal ion homeostasis and has been proposed as a promising vaccine candidate against pneumococcal disease. To investigate for potential… read more here.
Keywords: histidine triad; triad protein; presence; thermal stability ... See more keywords
Dynamic Long-Range Interactions Influence Substrate Binding and Catalysis by Human Histidine Triad Nucleotide-Binding Proteins (HINTs), Key Regulators of Multiple Cellular Processes and Activators of Antiviral ProTides.
Sign Up to like & getrecommendations! Published in 2022 at "Biochemistry"
DOI: 10.1021/acs.biochem.2c00506
Abstract: Human histidine triad nucleotide-binding (hHINT) proteins catalyze nucleotide phosphoramidase and acyl-phosphatase reactions that are essential for the activation of antiviral proTides, such as Sofosbuvir and Remdesivir. hHINT1 and hHINT2 are highly homologous but exhibit disparate… read more here.
Keywords: binding; long range; human histidine; nucleotide binding ... See more keywords
A Crystal Structure Based Guide to the Design of Human Histidine Triad Nucleotide Binding Protein 1 (hHint1) Activated ProTides.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.7b00664
Abstract: Nucleotide analogues that incorporate a metabolically labile nucleoside phosphoramidate (a ProTide) have found utility as prodrugs. In humans, ProTides can be cleaved by human histidine triad nucleotide binding protein 1 (hHint1) to expose the nucleotide… read more here.
Keywords: histidine triad; triad nucleotide; nucleotide binding; binding protein ... See more keywords
Potential Role of the Fragile Histidine Triad in Cancer Evo-Dev
Sign Up to like & getrecommendations! Published in 2023 at "Cancers"
DOI: 10.3390/cancers15041144
Abstract: Simple Summary Tumor development follows an evolutionary pattern of “mutation-selection-adaptation”, characterized by exogenous oncogenic induction and endogenous replicative stress. The fragile histidine triad (FHIT) is a tumor suppressor. Aberrant transcription or reduction in the transcription… read more here.
Keywords: evo dev; role; histidine triad; cancer evo ... See more keywords