P028 Immunogenicity of minor histocompatibility antigens may be dependent on the frequencies of naive precursor cells in the donor repertoire
Sign Up to like & getrecommendations! Published in 2017 at "Human Immunology"
DOI: 10.1016/j.humimm.2017.06.088
Abstract: Aim Out of 60+ minor histocompatibility antigens (MiHA) discovered so far some are immunodominant, i.e. almost universally cause allogeneic response when mismatched, while others are much less immunogenic. Before transplantation MiHA specific T cells reside… read more here.
Keywords: immunogenicity; histocompatibility antigens; minor histocompatibility; miha ... See more keywords
Towards Predicting Graft Vs Host Disease from Predicted Tissue Specific Minor Histocompatibility Antigens
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DOI: 10.1182/blood-2018-99-119783
Abstract: Graft versus host disease (GVHD) continues to be a life-threatening complication of stem cell transplantation for hematological malignancies. GVHD occurs in perfectly HLA-matched, related (MRD) transplants, and conversely can be absent in matched un-related (MUD)… read more here.
Keywords: histocompatibility antigens; mha; tissue; minor histocompatibility ... See more keywords
Computational modeling and confirmation of leukemia-associated minor histocompatibility antigens.
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DOI: 10.1182/bloodadvances.2018022475
Abstract: T-cell responses to minor histocompatibility antigens (mHAs) mediate both antitumor immunity (graft-versus-leukemia [GVL]) and graft-versus-host disease (GVHD) in allogeneic stem cell transplant. Identifying mHAs with high allele frequency, tight binding affinity to common HLA molecules,… read more here.
Keywords: leukemia associated; histocompatibility antigens; antigen; minor histocompatibility ... See more keywords