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   Articles with "histocompatibility complex" as a keyword



Origin and evolution of the major histocompatibility complex class I region in eutherian mammals

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recommendations! Published in 2019 at "Ecology and Evolution"

DOI: 10.1002/ece3.5373

Abstract: Abstract Major histocompatibility complex (MHC) genes in vertebrates are vital in defending against pathogenic infections. To gain new insights into the evolution of MHC Class I (MHCI) genes and test competing hypotheses on the origin… read more here.

Keywords: region; major histocompatibility; histocompatibility complex; class ... See more keywords

Novel Presentation of Major Histocompatibility Complex Class II Deficiency with Hemophagocytic Lymphohistiocytosis

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recommendations! Published in 2024 at "Journal of Clinical Immunology"

DOI: 10.1007/s10875-024-01674-0

Abstract: Major histocompatibility complex (MHC) class II deficiency is one of the combined immune deficiency disorders caused by defects in the MHC class II regulatory genes leading to abnormal T cells development and function. Therefore, patients… read more here.

Keywords: class deficiency; mhc class; major histocompatibility; class ... See more keywords
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Multiple major histocompatibility complex class I genes in Asian anurans: Ontogeny and phylogeny

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recommendations! Published in 2017 at "Developmental and Comparative Immunology"

DOI: 10.1016/j.dci.2016.12.003

Abstract: ABSTRACT Amphibians, as the first terrestrial vertebrates, offer a window into early major histocompatibility complex (MHC) evolution. We characterized the MHC class I of two Korean amphibians, the Asiatic toad (Bufo gargarizans) and the Japanese… read more here.

Keywords: class; histocompatibility complex; major histocompatibility; mhc ... See more keywords

Characterisation of major histocompatibility complex class I transcripts in an Australian dragon lizard

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recommendations! Published in 2018 at "Developmental and Comparative Immunology"

DOI: 10.1016/j.dci.2018.02.012

Abstract: &NA; Characterisation of squamate major histocompatibility complex (MHC) genes has lagged behind other taxonomic groups. MHC genes encode cell‐surface glycoproteins that present self‐ and pathogen‐derived peptides to T cells and play a critical role in… read more here.

Keywords: class; histocompatibility complex; class transcripts; major histocompatibility ... See more keywords

More than skin deep: Major histocompatibility complex (MHC)-based attraction among Asian American speed-daters

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recommendations! Published in 2018 at "Evolution and Human Behavior"

DOI: 10.1016/j.evolhumbehav.2018.04.001

Abstract: Abstract What might explain our instinctual attraction to certain individuals, aside from visible factors such as appearance? We examined possible biologically-driven selection for immunology genes, specifically preferences for Major Histocompatibility Complex (MHC)-dissimilarity, through the ecologically-valid… read more here.

Keywords: histocompatibility complex; complex mhc; mhc based; speed ... See more keywords

Identification of monoclonal antibodies cross-reactive with bottlenose dolphin orthologues of the major histocompatibility complex and leukocyte differentiation molecules.

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recommendations! Published in 2017 at "Veterinary immunology and immunopathology"

DOI: 10.1016/j.vetimm.2017.09.007

Abstract: The slow progress in understanding immunotoxic effects of environmental contaminants and their influence on disease susceptibility in whales is largely due to the limited information available on the immune systems and immune function of species… read more here.

Keywords: differentiation molecules; leukocyte differentiation; histocompatibility complex; cross reactive ... See more keywords
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Adaptive selection signatures in river buffalo with emphasis on immune and major histocompatibility complex genes.

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recommendations! Published in 2021 at "Genomics"

DOI: 10.1016/j.ygeno.2021.08.021

Abstract: River buffalo is an agriculturally important species with many traits, such as disease tolerance, which promote its use worldwide. Highly contiguous genome assemblies of the river buffalo, goat, pig, human and two cattle subspecies were… read more here.

Keywords: immune; river buffalo; histocompatibility complex; selection ... See more keywords

RLpMIEC: High-Affinity Peptide Generation Targeting Major Histocompatibility Complex-I Guided and Interpreted by Interaction Spectrum-Navigated Reinforcement Learning

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recommendations! Published in 2024 at "Journal of chemical information and modeling"

DOI: 10.1021/acs.jcim.4c01153

Abstract: Major histocompatibility complex (MHC) plays a vital role in presenting epitopes (short peptides from pathogenic proteins) to T-cell receptors (TCRs) to trigger the subsequent immune responses. Vaccine design targeting MHC generally aims to find epitopes… read more here.

Keywords: major histocompatibility; affinity; histocompatibility complex; interaction ... See more keywords
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Destabilizing single chain major histocompatibility complex class I protein for repurposed enterokinase proteolysis

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recommendations! Published in 2020 at "Scientific Reports"

DOI: 10.1038/s41598-020-71785-2

Abstract: The lack of a high throughput assay for screening stabilizing peptides prior to building a library of peptide-major histocompatibility complex class I (pMHC-I) molecules has motivated the continual use of in silico tools without biophysical… read more here.

Keywords: protein; chain; histocompatibility complex; major histocompatibility ... See more keywords

Heterozygosity of the major histocompatibility complex predicts later self-reported pubertal maturation in men

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recommendations! Published in 2021 at "Scientific Reports"

DOI: 10.1038/s41598-021-99334-5

Abstract: Individual variation in the age of pubertal onset is linked to physical and mental health, yet the factors underlying this variation are poorly understood. Life history theory predicts that individuals at higher risk of mortality… read more here.

Keywords: reported pubertal; histocompatibility complex; heterozygosity major; major histocompatibility ... See more keywords

Europeans and Americans of European origin show differences between their biological pathways related to the major histocompatibility complex

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recommendations! Published in 2024 at "Scientific Reports"

DOI: 10.1038/s41598-024-71803-7

Abstract: In this study, we analysed biological pathway diversity among Europeans and Northern Americans of European origin, the groups of people that share a common genetic ancestry but live in different geographic regions. We used a… read more here.

Keywords: major histocompatibility; biological pathways; americans european; europeans americans ... See more keywords