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   Articles with "histone" as a keyword



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Linker histone H1FOO regulates the chromatin structure in mouse zygotes

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recommendations! Published in 2018 at "FEBS Letters"

DOI: 10.1002/1873-3468.13175

Abstract: The chromatin structure in one‐cell‐stage mouse embryos is extremely loose and becomes tighter at the two‐cell stage. As linker histones are involved in higher‐order chromatin structure, we examined the involvement of the linker histone variant… read more here.

Keywords: chromatin structure; h1foo; structure; cell ... See more keywords
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Mechanistic and structural studies of KDM‐catalysed demethylation of histone 1 isotype 4 at lysine 26

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recommendations! Published in 2018 at "Febs Letters"

DOI: 10.1002/1873-3468.13231

Abstract: N‐Methylation of lysyl residues is widely observed on histone proteins. Using isolated enzymes, we report mechanistic and structural studies on histone lysine demethylase (KDM)‐catalysed demethylation of Nε‐methylated lysine 26 on histone 1 isotype 4 (H1.4).… read more here.

Keywords: kdm catalysed; demethylation; structural studies; catalysed demethylation ... See more keywords
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Histone-lysine N-methyltransferase EHMT2 (G9a) inhibition mitigates tumorigenicity in Myc-driven liver cancer.

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recommendations! Published in 2023 at "Molecular oncology"

DOI: 10.1002/1878-0261.13417

Abstract: Hepatocellular carcinoma (HCC) is the third deadliest and sixth most common cancer in the world. Histone-lysine N-methyltransferase EHMT2 (also known as G9a) is a histone methyltransferase frequently overexpressed in many cancer types, including HCC. We… read more here.

Keywords: driven liver; histone; g9a; myc driven ... See more keywords
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Nutrient Sensing by Histone Marks: Reading the Metabolic Histone Code Using Tracing, Omics, and Modeling

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recommendations! Published in 2020 at "BioEssays"

DOI: 10.1002/bies.202000083

Abstract: Several metabolites serve as substrates for histone modifications and communicate changes in the metabolic environment to the epigenome. Technologies such as metabolomics and proteomics have allowed us to reconstruct the interactions between metabolic pathways and… read more here.

Keywords: sensing histone; reading metabolic; histone marks; marks reading ... See more keywords
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Slowly on, Slowly off: Bisubstrate‐Analogue Conjugates of 5‐Iodotubercidin and Histone H3 Peptide Targeting Protein Kinase Haspin

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recommendations! Published in 2017 at "ChemBioChem"

DOI: 10.1002/cbic.201600697

Abstract: The atypical protein kinase haspin is a key player in mitosis by catalysing the phosphorylation of Thr3 in histone H3, and thus ensuring the normal function of the chromosomal passenger complex. Here, we report the development… read more here.

Keywords: kinase haspin; kinase; bisubstrate analogue; protein kinase ... See more keywords
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Lysine‐241 Has a Role in Coupling 2OG Turnover with Substrate Oxidation During KDM4‐Catalysed Histone Demethylation

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recommendations! Published in 2018 at "Chembiochem"

DOI: 10.1002/cbic.201800002

Abstract: The JmjC histone lysyl demethylases (KDMs) play important roles in modulating histone methylation states and have the potential to be regulated by oxygen availability. Lys241 of the KDM4 subfamily is proposed to be important in… read more here.

Keywords: substrate oxidation; oxidation; role coupling; lysine 241 ... See more keywords
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Peptides Derived from Histone 3 and Modified at Position 18 Inhibit Histone Demethylase KDM6 Enzymes

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recommendations! Published in 2018 at "ChemBioChem"

DOI: 10.1002/cbic.201800185

Abstract: The KDM6 subfamily of histone lysine demethylases has recently been implicated as a putative target in the treatment of a number of diseases; this makes the availability of potent and selective inhibitors important. Due to… read more here.

Keywords: kdm6 enzymes; derived histone; peptides derived; histone modified ... See more keywords
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Protein Arginine Methyltransferase 1‐Dependent Labeling and Isolation of Histone H4 through N‐Mustard Analogues of S‐Adenosyl‐l‐methionine

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recommendations! Published in 2019 at "ChemBioChem"

DOI: 10.1002/cbic.201800477

Abstract: Histones, the fundamental building blocks of nucleosomes, undergo post‐translational modifications and play a major role in the regulation of transcriptional processes. Although the significance of these modifications, including methylation, is widely recognized, little is known… read more here.

Keywords: adenosyl methionine; protein arginine; analogues adenosyl; mustard analogues ... See more keywords
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Covalent Modification of Bromodomain Proteins by Peptides Containing a DNA Damage‐Induced, Histone Post‐Translational Modification

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recommendations! Published in 2022 at "ChemBioChem"

DOI: 10.1002/cbic.202200373

Abstract: An electrophilic 5‐methylene‐2‐pyrrolone modification (KMP) is produced at lysine residues of histone proteins in nucleosome core particles upon reaction with a commonly formed DNA lesion (C4‐AP). The nonenzymatic KMP modification is also generated in the… read more here.

Keywords: modification; histone; kmp; bromodomain ... See more keywords
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Design and Synthesis of C3‐Substituted β‐Carboline‐Based Histone Deacetylase Inhibitors with Potent Antitumor Activities

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recommendations! Published in 2017 at "ChemMedChem"

DOI: 10.1002/cmdc.201700133

Abstract: A series of hydroxamic acid histone deacetylase (HDAC) inhibitors in which the β‐carboline motif has been incorporated were designed and synthesized. The effect of substitution at the C3 amide on HDAC inhibition and antiproliferative activities… read more here.

Keywords: design synthesis; histone; carboline based; histone deacetylase ... See more keywords
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Novel histone deacetylase inhibitors bearing a 4‐piperidin‐4‐yl‐triazole scaffold as antitumor agents

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recommendations! Published in 2019 at "Drug Development Research"

DOI: 10.1002/ddr.21603

Abstract: Histone deacetylases have proven to be promising targets for the development of anticancer drugs. In this work, we reported the design and synthesis of a series of 20 novel hydroxamic acid‐based histone deacetylase inhibitors with… read more here.

Keywords: novel histone; deacetylase inhibitors; histone deacetylase; piperidin triazole ... See more keywords