Inhibition of histone acetylation and deacetylation enzymes affects longevity, development, and fecundity in the pea aphid (Acyrthosiphon pisum).
Sign Up to like & getrecommendations! Published in 2019 at "Archives of insect biochemistry and physiology"
DOI: 10.1002/arch.21614
Abstract: Histone acetylation is an evolutionarily conserved epigenetic mechanism of eukaryotic gene regulation which is tightly controlled by the opposing activities of histone acetyltransferases (HATs) and histone deacetylases (HDACs). In insects, life-history traits such as longevity… read more here.
Keywords: histone acetylation; inhibition; aphid acyrthosiphon; acyrthosiphon pisum ... See more keywords
An enriched environment improves maternal sleep deprivation-induced cognitive deficits and synaptic plasticity via hippocampal histone acetylation.
Sign Up to like & getrecommendations! Published in 2023 at "Brain and behavior"
DOI: 10.1002/brb3.3018
Abstract: INTRODUCTION Growing evidence clearly demonstrates that maternal rodents exposure to sleep deprivation (SD) during late pregnancy impairs learning and memory in their offspring. Epigenetic mechanisms, particularly histone acetylation, are known to be involved in synaptic… read more here.
Keywords: memory; synaptic plasticity; acetylation; histone acetylation ... See more keywords
Brain region‐specific regulation of histone acetylation and efflux transporters in mice
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.22318
Abstract: Multidrug resistance protein 1 (MDR1) and breast cancer resistance protein (BCRP) protect the brain by restricting the passage of chemicals across the blood‐brain barrier. Prior studies have demonstrated the epigenetic regulation of MDR1 and BCRP… read more here.
Keywords: protein; histone acetylation; brain; regulation ... See more keywords
Coordinated expression of p300 and HDAC3 upregulates histone acetylation during dentinogenesis
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.29470
Abstract: Cellular differentiation is caused by highly controlled modifications in the gene expression but rarely involves a change in the DNA sequence itself. Histone acetylation is a major epigenetic factor that adds an acetyl group to… read more here.
Keywords: dentinogenesis; histone acetylation; acetylation; odontoblast differentiation ... See more keywords
Acetyl‐CoA synthases are essential for maintaining histone acetylation under metabolic stress during zygotic genome activation in pigs
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30355
Abstract: ACSS1/2 converts acetate into acetyl‐coenzyme A, which contributes to histone acetylation in the mitochondria and cytoplasm. Zygotic genome activation (ZGA) is critical for embryo development involving drastic histone modification. An efficient crRNAs‐Cas13a targeting strategy was… read more here.
Keywords: acss1; histone acetylation; acetylation; metabolic stress ... See more keywords
Stimulation of Fas/FasL‐mediated apoptosis by luteolin through enhancement of histone H3 acetylation and c‐Jun activation in HL‐60 leukemia cells
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.22807
Abstract: Luteolin (3′,4′,5,7‐tetrahydroxyflavone), which exists in fruits, vegetables, and medicinal herbs, is used in Chinese traditional medicine for treating various diseases, such as hypertension, inflammatory disorders, and cancer. However, the gene‐regulatory role of luteolin in cancer… read more here.
Keywords: histone acetylation; acetylation; jun; fas fasl ... See more keywords
Isolation and Quantification Brain Region-Specific and Cell Subtype-Specific Histone (De)Acetylation in Cognitive Neuroepigenetics.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9434-2_16
Abstract: The acetylation of histone tails, which relaxes compact chromatin structure and enhances the accessibility of DNA to regulatory proteins, has emerged as a key mechanism for regulating gene expression. These modifications in turn play critical… read more here.
Keywords: histone acetylation; specific cell; brain; specific histone ... See more keywords
A translational perspective on histone acetylation modulators in psychiatric disorders
Sign Up to like & getrecommendations! Published in 2018 at "Psychopharmacology"
DOI: 10.1007/s00213-018-4947-z
Abstract: A large volume of research now provides evidence correlating aberrant histone deacetylase (HDAC) activities and hypoacetylation of histones to disruptions in synaptic plasticity, neuronal survival/regeneration, memory formation and consolidation. Hence, maintaining the acetyl-histone homeostasis as… read more here.
Keywords: acetylation modulators; histone acetylation; psychiatric disorders; translational perspective ... See more keywords
Fng1 is involved in crosstalk between histone acetylation and methylation.
Sign Up to like & getrecommendations! Published in 2021 at "Current genetics"
DOI: 10.1007/s00294-021-01167-2
Abstract: The histone modifications usually form complicated networks to regulate accessibility of DNA and transcription. Identification of proteins that are involved in the crosstalk among different histone modifications will help to better understand the epigenetic regulatory… read more here.
Keywords: histone acetylation; crosstalk histone; fng1 involved; involved crosstalk ... See more keywords
Inactivation of the Schizophrenia-associated BRD1 gene in Brain Causes Failure-to-thrive, Seizure Susceptibility and Abnormal Histone H3 Acetylation and N-tail Clipping.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular neurobiology"
DOI: 10.1007/s12035-021-02432-8
Abstract: Genetic studies have repeatedly shown that the Bromodomain containing 1 gene, BRD1, is involved in determining mental health, and the importance of the BRD1 protein for normal brain function has been studied in both cell… read more here.
Keywords: histone acetylation; tail clipping; gene; brain ... See more keywords
Decreased level of histone acetylation in the infralimbic prefrontal cortex following immediate extinction may result in deficit of extinction memory
Sign Up to like & getrecommendations! Published in 2018 at "Brain Research Bulletin"
DOI: 10.1016/j.brainresbull.2018.06.004
Abstract: In the last few decades, there has been exponential increase in studies aiming to trace the molecular mechanism of fear extinction with a hope to minimize the return of fear after exposure therapy required for… read more here.
Keywords: immediate extinction; extinction; histone acetylation; extinction group ... See more keywords