Design, synthesis, and biological evaluation of a new class of histone acetyltransferase p300 inhibitors.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2019.07.026
Abstract: p300 is an important histone acetyltransferase in epigenetics, and its overexpression is closely related to various diseases such as cancers. C646 is one of the most representative p300 inhibitors and used in various studies of… read more here.
Keywords: p300 inhibitors; histone acetyltransferase; activity; p300 ... See more keywords
Histone Acetyltransferase 1 Links Metabolism and Transcription to Cell-Cycle Progression.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular cell"
DOI: 10.1016/j.molcel.2019.08.004
Abstract: HAT1 is an essential gene in mammals that acetylates newly synthesized histone H4 and is involved in chromatin assembly and genome maintenance. In this issue of Molecular Cell, Gruber et al. (2019) show that HAT1 binds… read more here.
Keywords: links metabolism; metabolism transcription; histone acetyltransferase; acetyltransferase links ... See more keywords
Dynamics of the Histone Acetyltransferase Lysine-Rich Loop in the Catalytic Core of the CREB-Binding Protein
Sign Up to like & getrecommendations! Published in 2022 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.1c01423
Abstract: The tight control of transcriptional coactivators is a fundamental aspect of gene expression in cells. The regulation of the CREB-binding protein (CBP) and p300 coactivators, two paralog multidomain proteins, involves an autoinhibitory loop (AIL) of… read more here.
Keywords: binding protein; histone acetyltransferase; ail; creb binding ... See more keywords
Recent Advances on Small-Molecule Bromodomain-Containing Histone Acetyltransferase Inhibitors.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c01638
Abstract: In recent years, substantial research has been conducted on molecular mechanisms and inhibitors targeting bromodomains (BRDs) and extra-terminal (BET) family proteins. On this basis, non-BET BRD is gradually becoming a research hot spot. BRDs are… read more here.
Keywords: small molecule; brd containing; histone acetyltransferase;
Histone acetyltransferase and Polo-like kinase 3 inhibitors prevent rat galactose-induced cataract
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-56414-x
Abstract: Diabetic cataracts can occur at an early age, causing visual impairment or blindness. The detailed molecular mechanisms of diabetic cataract formation remain incompletely understood, and there is no well-documented prophylactic agent. Galactose-fed rats and ex… read more here.
Keywords: formation; induced cataract; galactose induced; histone acetyltransferase ... See more keywords
Structure of the NuA4 histone acetyltransferase complex
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2214313119
Abstract: Significance The structure of NuA4, one of two major histone acetyltransferases of Saccharomyces cerevisiae, is reported at 3.8 Å resolution. Six polypeptide chains of the complex, comprising about half the total mass, could be traced.… read more here.
Keywords: structure; histone acetyltransferase; nua4 histone; acetyltransferase complex ... See more keywords
Combination Treatments with Luteolin and Fisetin Enhance Anti-Inflammatory Effects in High Glucose-Treated THP-1 Cells Through Histone Acetyltransferase/Histone Deacetylase Regulation.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of medicinal food"
DOI: 10.1089/jmf.2017.3968
Abstract: Hyperglycemia leads to diabetes and its diabetic complications. In this study, we investigated the synergistic effects of luteolin and fisetin on proinflammatory cytokine secretion and its underlying epigenetic regulation in human monocytes exposed to hyperglycemic… read more here.
Keywords: combination; luteolin fisetin; combination treatments; treatments luteolin ... See more keywords
A role for the Saccharomyces cerevisiae Rtt109 histone acetyltransferase in R-loop homeostasis and associated genome instability
Sign Up to like & getrecommendations! Published in 2022 at "Genetics"
DOI: 10.1093/genetics/iyac108
Abstract: Abstract The stability of the genome is occasionally challenged by the formation of DNA–RNA hybrids and R-loops, which can be influenced by the chromatin context. This is mainly due to the fact that DNA–RNA hybrids… read more here.
Keywords: histone acetyltransferase; rtt109 histone; instability; saccharomyces cerevisiae ... See more keywords
Early‐onset aging and mitochondrial defects associated with loss of histone acetyltransferase 1 (Hat1)
Sign Up to like & getrecommendations! Published in 2019 at "Aging Cell"
DOI: 10.1111/acel.12992
Abstract: Histone acetyltransferase 1 (Hat1) is responsible for the acetylation of newly synthesized histone H4 on lysines 5 and 12 during the process of chromatin assembly. To understand the broader biological role of Hat1, we have… read more here.
Keywords: early onset; hat1; acetyltransferase hat1; onset aging ... See more keywords
Molecular Architecture of the Essential Yeast Histone Acetyltransferase Complex NuA4 Redefines Its Multimodularity
Sign Up to like & getrecommendations! Published in 2018 at "Molecular and Cellular Biology"
DOI: 10.1128/mcb.00570-17
Abstract: ABSTRACT Conserved from yeast to humans, the NuA4 histone acetyltransferase is a large multisubunit complex essential for cell viability through the regulation of gene expression, genome maintenance, metabolism, and cell fate during development and stress.… read more here.
Keywords: histone acetyltransferase; architecture; nua4; molecular architecture ... See more keywords
Histone Acetyltransferase-Dependent Pathways Mediate Upregulation of NADPH Oxidase 5 in Human Macrophages under Inflammatory Conditions: A Potential Mechanism of Reactive Oxygen Species Overproduction in Atherosclerosis
Sign Up to like & getrecommendations! Published in 2019 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2019/3201062
Abstract: Histone acetylation plays a major role in epigenetic regulation of gene expression. Monocyte-derived macrophages express functional NADPH oxidase 5 (Nox5) that contributes to oxidative stress in atherogenesis. The mechanisms of Nox5 regulation are not entirely… read more here.
Keywords: human macrophages; histone acetyltransferase; histone; p300 hat1 ... See more keywords