The histone chaperone HIR maintains chromatin states to control nitrogen assimilation and fungal virulence
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.109406
Abstract: SUMMARY Adaptation to changing environments and immune evasion is pivotal for fitness of pathogens. Yet, the underlying mechanisms remain largely unknown. Adaptation is governed by dynamic transcriptional re-programming, which is tightly connected to chromatin architecture.… read more here.
Keywords: virulence; hir; histone chaperone; fungal virulence ... See more keywords
The histone chaperone FACT facilitates heterochromatin spreading by regulating histone turnover and H3K9 methylation states
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.109944
Abstract: SUMMARY Heterochromatin formation requires three distinct steps: nucleation, self-propagation (spreading) along the chromosome, and faithful maintenance after each replication cycle. Impeding any of those steps induces heterochromatin defects and improper gene expression. The essential histone… read more here.
Keywords: histone chaperone; histone turnover; heterochromatin spreading; fact ... See more keywords
The Histone Chaperone FACT Coordinates H2A.X-Dependent Signaling and Repair of DNA Damage
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Cell"
DOI: 10.1016/j.molcel.2018.09.010
Abstract: Summary Safeguarding cell function and identity following a genotoxic stress challenge entails a tight coordination of DNA damage signaling and repair with chromatin maintenance. How this coordination is achieved and with what impact on chromatin… read more here.
Keywords: dna damage; signaling repair; histone chaperone; damage ... See more keywords
Histone chaperone networks shaping chromatin function
Sign Up to like & getrecommendations! Published in 2017 at "Nature Reviews Molecular Cell Biology"
DOI: 10.1038/nrm.2016.159
Abstract: The association of histones with specific chaperone complexes is important for their folding, oligomerization, post-translational modification, nuclear import, stability, assembly and genomic localization. In this way, the chaperoning of soluble histones is a key determinant… read more here.
Keywords: histone chaperone; chaperone networks; shaping chromatin; networks shaping ... See more keywords
Dynamic intramolecular regulation of the histone chaperone nucleoplasmin controls histone binding and release
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/s41467-017-02308-3
Abstract: Nucleoplasmin (Npm) is a highly conserved histone chaperone responsible for the maternal storage and zygotic release of histones H2A/H2B. Npm contains a pentameric N-terminal core domain and an intrinsically disordered C-terminal tail domain. Though intrinsically… read more here.
Keywords: tail domain; histone binding; histone; histone chaperone ... See more keywords
USP52 acts as a deubiquitinase and promotes histone chaperone ASF1A stabilization
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-03588-z
Abstract: Histone chaperone ASF1A has been reported to be dysregulated in multiple tumors; however, the underlying molecular mechanism that how the abundance and function of ASF1A are regulated remains unclear. Here we report that ASF1A is… read more here.
Keywords: chaperone asf1a; stabilization; histone chaperone; asf1a stabilization ... See more keywords
OsChz1 acts as a histone chaperone in modulating chromatin organization and genome function in rice
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-19586-z
Abstract: While the yeast Chz1 acts as a specific histone-chaperone for H2A.Z, functions of CHZ-domain proteins in multicellular eukaryotes remain obscure. Here, we report on the functional characterization of OsChz1, a sole CHZ-domain protein identified in… read more here.
Keywords: h2a h2b; chaperone; rice oschz1; histone chaperone ... See more keywords
Phosphorylation of the FACT histone chaperone subunit SPT16 affects chromatin at RNA polymerase II transcriptional start sites in Arabidopsis
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac293
Abstract: Abstract The heterodimeric histone chaperone FACT, consisting of SSRP1 and SPT16, contributes to dynamic nucleosome rearrangements during various DNA-dependent processes including transcription. In search of post-translational modifications that may regulate the activity of FACT, SSRP1… read more here.
Keywords: histone; rna polymerase; fact; polymerase transcriptional ... See more keywords
A potential histone-chaperone activity for the MIER1 histone deacetylase complex.
Sign Up to like & getrecommendations! Published in 2023 at "Nucleic acids research"
DOI: 10.1093/nar/gkad294
Abstract: Histone deacetylases 1 and 2 (HDAC1/2) serve as the catalytic subunit of six distinct families of nuclear complexes. These complexes repress gene transcription through removing acetyl groups from lysine residues in histone tails. In addition… read more here.
Keywords: activity mier1; histone; deacetylase; chaperone activity ... See more keywords
Histone chaperone Nap1 dismantles an H2A/H2B dimer from a partially unwrapped nucleosome.
Sign Up to like & getrecommendations! Published in 2023 at "Nucleic acids research"
DOI: 10.1093/nar/gkad396
Abstract: DNA translocases, such as RNA polymerases, inevitably collide with nucleosomes on eukaryotic chromatin. Upon these collisions, histone chaperones are suggested to facilitate nucleosome disassembly and re-assembly. In this study, by performing in vitro transcription assays… read more here.
Keywords: histone chaperones; histone; h2b dimer; h2a h2b ... See more keywords
Histone chaperone activity of Arabidopsis thaliana NRP1 is blocked by cytochrome c
Sign Up to like & getrecommendations! Published in 2017 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkw1215
Abstract: Abstract Higher-order plants and mammals use similar mechanisms to repair and tolerate oxidative DNA damage. Most studies on the DNA repair process have focused on yeast and mammals, in which histone chaperone-mediated nucleosome disassembly/reassembly is… read more here.
Keywords: dna; arabidopsis thaliana; histone chaperone; chaperone ... See more keywords