Recognition of Histone Crotonylation by Taf14 Links Metabolic State to Gene Expression.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular cell"
DOI: 10.1016/j.molcel.2019.09.029
Abstract: Metabolic signaling to chromatin often underlies how adaptive transcriptional responses are controlled. While intermediary metabolites serve as co-factors for histone-modifying enzymes during metabolic flux, how these modifications contribute to transcriptional responses is poorly understood. Here,… read more here.
Keywords: crotonylation; gene expression; histone crotonylation;
Hypoxia Increases ATX Expression by Histone Crotonylation in a HIF-2α-Dependent Manner
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24087031
Abstract: Autotaxin (ATX), the key enzyme that generates lysophosphatidic acid (LPA) from lysophosphatidylcholine (LPC), is involved in tumorigenesis through the ATX-LPA axis and is regarded as a valuable target in tumor therapy. Hypoxia is a major… read more here.
Keywords: hypoxia; histone crotonylation; atx expression; expression ... See more keywords