T‐17, a novel cyclin‐dependent kinases/histone deacetylases dual inhibitor, induces cancer cells death through cell cycle arrest and apoptosis
Sign Up to like & getrecommendations! Published in 2022 at "Drug Development Research"
DOI: 10.1002/ddr.21977
Abstract: Combination of cyclin‐dependent kinases (CDKs) and histone deacetylases (HDACs) inhibitors may have statistical synergy in suppressing cancer cell proliferation. Herein, a novel CDKs/HDACs dual inhibitor T‐17 was rationally designed, synthesized, and evaluated. Our results demonstrated… read more here.
Keywords: cell; dual inhibitor; cyclin dependent; histone deacetylases ... See more keywords
The role of histone deacetylases in embryonic development
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Reproduction and Development"
DOI: 10.1002/mrd.23659
Abstract: The basic units of chromatin are nucleosomes, that are made up of DNA wrapped around histone cores. Histone lysine residue is a common location for posttranslational modifications, with acetylation being the second most prevalent. Histone… read more here.
Keywords: embryonic development; hdacs kdacs; histone; role ... See more keywords
The histone deacetylases HDAC1 and HDAC2 are required for the growth and survival of renal carcinoma cells
Sign Up to like & getrecommendations! Published in 2018 at "Archives of Toxicology"
DOI: 10.1007/s00204-018-2229-5
Abstract: Novel therapies are required for the treatment of metastatic renal cell carcinoma (RCC), which is associated with inoperable disease and patient death. Histone deacetylases (HDACs) are epigenetic modifiers and potential drug targets. Additional information on… read more here.
Keywords: carcinoma; deacetylases hdac1; histone deacetylases; renal carcinoma ... See more keywords
Comparative Genome-Wide Analysis and Expression Profiling of Histone Acetyltransferases and Histone Deacetylases Involved in the Response to Drought in Wheat
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Plant Growth Regulation"
DOI: 10.1007/s00344-021-10364-9
Abstract: Histone acetyltransferases (HATs) and histone deacetylases (HDACs) contribute to plant growth, development, and stress responses. A number of HAT and HDAC genes have been identified in several plants. However, wheat HATs and HDACs have not… read more here.
Keywords: histone deacetylases; wheat; histone acetyltransferases; histone ... See more keywords
Functions and mechanisms of plant histone deacetylases
Sign Up to like & getrecommendations! Published in 2019 at "Science China Life Sciences"
DOI: 10.1007/s11427-019-1587-x
Abstract: Lysine acetylation, one of the major types of post-translational modifications, plays critical roles in regulating gene expression and protein function. Histone deacetylases (HDACs) are responsible for removing acetyl groups from lysines of both histone and… read more here.
Keywords: plant; functions mechanisms; histone deacetylases; mechanisms plant ... See more keywords
Histone deacetylases inhibitors as new potential drugs against Leishmania braziliensis, the main causative agent of New World Tegumentary Leishmaniasis.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2020.114191
Abstract: The protozoan parasite Leishmania braziliensis is a major causative agent of the neglected tropical diseases Cutaneous and Mucocutaneous Leishmaniases in the New World. There are no vaccines to prevent the infection and the treatment relies… read more here.
Keywords: leishmania braziliensis; new world; braziliensis; causative agent ... See more keywords
Histone deacetylases as an epigenetic pillar for the development of hybrid inhibitors in cancer.
Sign Up to like & getrecommendations! Published in 2019 at "Current opinion in chemical biology"
DOI: 10.1016/j.cbpa.2019.03.002
Abstract: The polypharmacology strategy of multi-targeting drugs acting on different biological pathways is capturing the researchers' attention, particularly in cancer. The simultaneous inhibition of two or more targets by drug combination or by a single 'hybrid… read more here.
Keywords: histone deacetylases; cancer; deacetylases epigenetic; epigenetic pillar ... See more keywords
Induced protein degradation of histone deacetylases 3 (HDAC3) by proteolysis targeting chimera (PROTAC).
Sign Up to like & getrecommendations! Published in 2020 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2020.112800
Abstract: Histone deacetylases (HDACs) play important roles in inflammatory diseases like asthma and chronic obstructive pulmonary disease (COPD). Unravelling of and interfering with the functions of specific isoenzymes contributing to inflammation provides opportunities for drug development.… read more here.
Keywords: proteolysis targeting; protac; degradation; histone deacetylases ... See more keywords
Comparative effects of histone deacetylases inhibitors and resveratrol on Trypanosoma cruzi replication, differentiation, infectivity and gene expression
Sign Up to like & getrecommendations! Published in 2017 at "International Journal for Parasitology: Drugs and Drug Resistance"
DOI: 10.1016/j.ijpddr.2016.12.003
Abstract: Histone post-translational modification, mediated by histone acetyltransferases and deacetylases, is one of the most studied factors affecting gene expression. Recent data showing differential histone acetylation states during the Trypanosoma cruzi cell cycle suggest a role… read more here.
Keywords: histone deacetylases; histone; cruzi; gene expression ... See more keywords
Structure, mechanism, and inhibition of the zinc-dependent histone deacetylases.
Sign Up to like & getrecommendations! Published in 2019 at "Current opinion in structural biology"
DOI: 10.1016/j.sbi.2019.01.004
Abstract: Zinc-dependent histone deacetylases (HDACs) regulate the biological function of histone and non-histone proteins through the hydrolysis of acetyllysine side chains to yield free lysine and acetate. Certain HDAC isozymes exhibit alternative catalytic activities, such as… read more here.
Keywords: zinc dependent; structure mechanism; dependent histone; histone deacetylases ... See more keywords
Targeting Class I Histone Deacetylases in a "Complex" Environment.
Sign Up to like & getrecommendations! Published in 2017 at "Trends in pharmacological sciences"
DOI: 10.1016/j.tips.2016.12.006
Abstract: Histone deacetylase (HDAC) inhibitors are proven anticancer therapeutics and have potential in the treatment of many other diseases including HIV infection, Alzheimer's disease, and Friedreich's ataxia. A problem with the currently available HDAC inhibitors is… read more here.
Keywords: deacetylases complex; class histone; complex environment; histone deacetylases ... See more keywords