Histone deacetylation regulates nucleotide excision repair through an interaction with the XPC protein
Sign Up to like & getrecommendations! Published in 2022 at "iScience"
DOI: 10.1016/j.isci.2022.104040
Abstract: Summary The XPC protein complex plays a central role in DNA lesion recognition for global genome nucleotide excision repair (GG-NER). Lesion recognition can be accomplished in either a UV-DDB-dependent or -independent manner; however, it is… read more here.
Keywords: xpc protein; nucleotide excision; histone deacetylation; xpc ... See more keywords
Symmetric dimethylation on histone H4R3 associates with histone deacetylation to maintain properly polarized cell growth.
Sign Up to like & getrecommendations! Published in 2019 at "Research in microbiology"
DOI: 10.1016/j.resmic.2019.09.007
Abstract: Yeast Hsl7 is recognized as a homolog of human arginine methyltransferase 5 (PRMT5) and shows type II PRMT activity by forming symmetric dimethylarginine residues on histones. Previously, we reported that Hsl7 is responsible for in… read more here.
Keywords: histone deacetylation; cell; histone; cell growth ... See more keywords
FOXO signaling pathway participates in oxidative stress-induced histone deacetylation
Sign Up to like & getrecommendations! Published in 2023 at "Free Radical Research"
DOI: 10.1080/10715762.2023.2190862
Abstract: Abstract High concentrations of antioxidants can exert pro-oxidative effects, elevate the level of intracellular reactive oxygen species (ROS), and cause oxidative stress in cells. We previously found that high concentrations of curcumin, a natural polyphenol… read more here.
Keywords: stress; signaling pathway; foxo signaling; oxidative stress ... See more keywords
A domesticated Harbinger transposase forms a complex with HDA6 and promotes histone H3 deacetylation at genes but not TEs in Arabidopsis.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of integrative plant biology"
DOI: 10.1111/jipb.13108
Abstract: In eukaryotes, histone acetylation is a major modification on histone N-terminal tails that is tightly connected to transcriptional activation. HDA6 is a histone deacetylase involved in the transcriptional regulation of genes and transposable elements (TEs)… read more here.
Keywords: tes arabidopsis; histone deacetylation; harbinger; domesticated harbinger ... See more keywords
Histone H4-Specific Deacetylation at Active Coding Regions by Hda1C
Sign Up to like & getrecommendations! Published in 2020 at "Molecules and Cells"
DOI: 10.14348/molcells.2020.0141
Abstract: Histone acetylation and deacetylation play central roles in the regulation of chromatin structure and transcription by RNA polymerase II (RNA Pol II). Although Hda1 histone deacetylase complex (Hda1C) is known to selectively deacetylate histone H3… read more here.
Keywords: specific deacetylation; hda1c; histone deacetylation; histone specific ... See more keywords
Pharmacological Histone Deacetylation Distinguishes Transcriptional Regulators.
Sign Up to like & getrecommendations! Published in 2017 at "Current topics in medicinal chemistry"
DOI: 10.2174/1568026617666161104104341
Abstract: INTRODUCTION Histone deacetylase (HDAC) enzymes control the acetylation status of transcription factors that regulate chromatin structure and gene function. The transcriptional regulatory factors that distinguish histone acetylation and deacetylation patterns by pharmacological HDAC inhibition (HDACi)… read more here.
Keywords: transcription; histone acetylation; histone deacetylation; deacetylation ... See more keywords
Histone Deacetylation Inhibitors as Therapy Concept in Sepsis
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms20020346
Abstract: Sepsis is characterized by dysregulated gene expression, provoking a hyper-inflammatory response occurring in parallel to a hypo-inflammatory reaction. This is often associated with multi-organ failure, leading to the patient’s death. Therefore, reprogramming of these pro-… read more here.
Keywords: histone deacetylation; sepsis; expression; deacetylation inhibitors ... See more keywords
Histone Deacetylation Inhibitors as Modulators of Regulatory T Cells
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms21072356
Abstract: Regulatory T cells (Tregs) are important mediators of immunological self-tolerance and homeostasis. Being cluster of differentiation 4+Forkhead box protein3+ (CD4+FOXP3+), these cells are a subset of CD4+ T lymphocytes and can originate from the thymus… read more here.
Keywords: histone deacetylation; inhibitors modulators; regulatory cells; modulators regulatory ... See more keywords
Histone deacetylase-2 is involved in stress-induced cognitive impairment via histone deacetylation and PI3K/AKT signaling pathway modification
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Medicine Reports"
DOI: 10.3892/mmr.2017.6840
Abstract: Exposure to chronic stress upregulates blood glucocorticoid levels and impairs cognition via diverse epigenetic mechanisms, such as histone deacetylation. Histone deacetylation can lead to transcriptional silencing of many proteins involved in cognition and may also… read more here.
Keywords: chronic stress; hdac2; histone deacetylation; stress ... See more keywords