Identification of the histone demethylases gene family in Glycyrrhiza inflata reveals genes responding to abiotic stresses
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.30315
Abstract: Glycyrrhiza inflata Bat. is a type of abiotic‐stress‐resistant plant with extremely high medicinal value. Histone demethylases (HDMTs) have been known to play crucial roles in the regulation of abiotic stress response. However, the molecular functions… read more here.
Keywords: gihdmt genes; stress; histone demethylases; abiotic stress ... See more keywords
Inhibition of KDM7A/B histone demethylases restores H3K79 methylation and protects against osteoarthritis
Sign Up to like & getrecommendations! Published in 2023 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/ard-2022-223789
Abstract: Objectives In osteoarthritis, methylation of lysine 79 on histone H3 (H3K79me), a protective epigenetic mechanism, is reduced. Histone methylation levels are dynamically regulated by histone methyltransferases and demethylases. Here, we aimed to identify which histone… read more here.
Keywords: methylation; histone; histone demethylases; protects osteoarthritis ... See more keywords
The JMJD Family Histone Demethylases in Crosstalk Between Inflammation and Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.881396
Abstract: Inflammation has emerged as a key player in regulating cancer initiation, progression, and therapeutics, acting as a double edged sword either facilitating cancer progression and therapeutic resistance or inducing anti-tumor immune responses. Accumulating evidence has… read more here.
Keywords: histone; histone demethylases; inflammation cancer; jmjd ... See more keywords
Histone Demethylases Coordinate the Antagonistic Interaction Between Abscisic Acid and Brassinosteroid Signaling in Arabidopsis
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2020.596835
Abstract: Abscisic acid (ABA) interacts antagonistically with brassinosteroids (BRs) to control plant growth and development in response to stress. The response to environmental cues includes hormonal control via epigenetic regulation of gene expression. However, the details… read more here.
Keywords: abscisic acid; histone demethylases; histone; antagonistic interaction ... See more keywords
Histone Demethylases JMJ30 and JMJ32 Modulate the Speed of Vernalization Through the Activation of FLOWERING LOCUS C in Arabidopsis thaliana
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2022.837831
Abstract: Vernalization is the promotion of flowering after prolonged exposure to cold. In Arabidopsis thaliana, vernalization induces epigenetic silencing of the floral repressor gene FLOWERING LOCUS C (FLC). Among the repressive epigenetic marks, the trimethylation of… read more here.
Keywords: vernalization; histone demethylases; arabidopsis thaliana; jmj30 jmj32 ... See more keywords
Small Molecule Inhibitors of KDM5 Histone Demethylases Increase the Radiosensitivity of Breast Cancer Cells Overexpressing JARID1B
Sign Up to like & getrecommendations! Published in 2019 at "Molecules"
DOI: 10.3390/molecules24091739
Abstract: Background: KDM5 enzymes are H3K4 specific histone demethylases involved in transcriptional regulation and DNA repair. These proteins are overexpressed in different kinds of cancer, including breast, prostate and bladder carcinomas, with positive effects on cancer… read more here.
Keywords: histone demethylases; breast; breast cancer; inhibitors kdm5 ... See more keywords
Functional Characterization of the Lysine-Specific Histone Demethylases Family in Soybean
Sign Up to like & getrecommendations! Published in 2022 at "Plants"
DOI: 10.3390/plants11111398
Abstract: Histone modifications, such as methylation and demethylation, have crucial roles in regulating chromatin structure and gene expression. Lysine-specific histone demethylases (LSDs) belong to the amine oxidase family, which is an important family of histone lysine… read more here.
Keywords: family; specific histone; histone; histone demethylases ... See more keywords
Targeting histone demethylases as a potential cancer therapy (Review).
Sign Up to like & getrecommendations! Published in 2022 at "International journal of oncology"
DOI: 10.3892/ijo.2022.5393
Abstract: Post‑translational modifications of histones by histone demethylases have an important role in the regulation of gene transcription and are implicated in cancers. Recently, the family of lysine (K)‑specific demethylase (KDM) proteins, referring to histone demethylases… read more here.
Keywords: histone; histone demethylases; review; cancer therapy ... See more keywords
Oncometabolite D-2-Hydroxyglutarate enhances gene silencing through inhibition of specific H3K36 histone demethylases
Sign Up to like & getrecommendations! Published in 2017 at "eLife"
DOI: 10.7554/elife.22451
Abstract: Certain mutations affecting central metabolism cause accumulation of the oncometabolite D-2-hydroxyglutarate which promotes progression of certain tumors. High levels of D-2-hydroxyglutarate inhibit the TET family of DNA demethylases and Jumonji family of histone demethylases and… read more here.
Keywords: histone demethylases; inhibition; hydroxyglutarate; gene ... See more keywords