A histone H2A-derived antimicrobial peptide, Hipposin from mangrove whip ray, Himantura walga: Molecular and functional characterisation
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DOI: 10.1007/s13205-020-02455-3
Abstract: Antimicrobial peptides (AMPs) are biologically dynamic molecules produced by all type of organisms as a fundamental component of their innate immune system. The present study deals with the identification of a histone H2A-derived antimicrobial peptide,… read more here.
Keywords: peptide; h2a derived; histone h2a; hipposin ... See more keywords
Maintenance of meiotic crossover against reduced double-strand break formation in fission yeast lacking histone H2A.Z.
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DOI: 10.1016/j.gene.2020.144615
Abstract: Meiotic crossover (CO) recombination initiates from programmed DNA double-strand breaks (DSBs) around hotspots, and results in reciprocal exchange of chromosome segments between homologous chromosomes (homologs). COs are crucial for most sexually-reproducing organisms because it promotes… read more here.
Keywords: formation; histone h2a; h2a; double strand ... See more keywords
Histone H2A Ubiquitination Reinforces Mechanical Stability and Asymmetry at Single-nucleosome Level.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.9b12448
Abstract: Mono-ubiquitination at Lysine 119 of H2A (ubH2A) is a prevalent post-translational modification and associated with gene repression in the context of chromatin. However, the direct function of ubH2A on nucleosome is poorly understood. Here we… read more here.
Keywords: histone h2a; asymmetry; h2a; ubh2a nucleosome ... See more keywords
Phosphorylation activates master growth regulator DELLA by promoting histone H2A binding at chromatin in Arabidopsis
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DOI: 10.1038/s41467-024-52033-x
Abstract: DELLA proteins are conserved master growth regulators that play a central role in controlling plant development in response to internal and environmental cues. DELLAs function as transcription regulators, which are recruited to target promoters by… read more here.
Keywords: phosphorylation; master growth; della; histone h2a ... See more keywords
Effects of charge-modifying mutations in histone H2A α3-domain on nucleosome stability assessed by single-pair FRET and MD simulations
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DOI: 10.1038/s41598-017-13416-x
Abstract: Nucleosomes are important for chromatin compaction and gene regulation; their integrity depends crucially on the structural properties of the histone tails. Recent all-atom molecular dynamics simulations revealed that removal of the N-terminal tails of histone… read more here.
Keywords: charge modifying; histone h2a; nucleosome stability; h2a ... See more keywords
A tale of two serines: the effects of histone H2A mutations S122A and S129A on chromosome nondisjunction in Saccharomyces cerevisiae
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DOI: 10.1093/genetics/iyae194
Abstract: Abstract Near the C-terminus of histone H2A in the yeast Saccharomyces cerevisiae, there are 2 serines (S122 and S129) that are targets of phosphorylation. The phosphorylation of serine 129 in response to DNA damage is… read more here.
Keywords: saccharomyces cerevisiae; phosphorylation; histone h2a; chromosome ... See more keywords
Crosstalks between NOD1 and Histone H2A Contribute to Host Defense against Streptococcus agalactiae Infection in Zebrafish
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DOI: 10.3390/antibiotics10070861
Abstract: Correlation studies about NOD1 and histones have not been reported. In the present study, we report the functional correlation between NOD1 and the histone H2A variant in response to Streptococcus agalactiae infection. In zebrafish, NOD1… read more here.
Keywords: histone h2a; nod1 histone; histone; agalactiae infection ... See more keywords
Immunohistochemical Pattern of Histone H2A Variant Expression in an Experimental Model of Ischemia–Reperfusion-Induced Acute Kidney Injury
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24098085
Abstract: Ischemia–reperfusion injury (IRI) is a frequent cause of AKI, resulting in vasoconstriction, cellular dysfunction, inflammation and the induction of oxidative stress. DNA damage, including physical DNA strand breaks, is also a potential consequence of renal… read more here.
Keywords: histone h2a; ischemia reperfusion; histone; expression ... See more keywords
White Tea Intake Abrogates Markers of Streptozotocin-Induced Prediabetes Oxidative Stress in Rat Lungs’
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DOI: 10.3390/molecules26133894
Abstract: Prediabetes (PrDM) is a prodromal stage of diabetes mellitus (DM) with an increasing prevalence worldwide. During DM progression, individuals gradually develop complications in various organs. However, lungs are suggested to be affected later than other… read more here.
Keywords: intake abrogates; tea intake; histone h2a; white tea ... See more keywords
Dual engagement of the nucleosomal acidic patches is essential for deposition of histone H2A.Z by SWR1C
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DOI: 10.7554/elife.94869
Abstract: The yeast SWR1C chromatin remodeling enzyme catalyzes the ATP-dependent exchange of nucleosomal histone H2A for the histone variant H2A.Z, a key variant involved in a multitude of nuclear functions. How the 14-subunit SWR1C engages the… read more here.
Keywords: nucleosomal acidic; deposition; acidic patch; histone h2a ... See more keywords