Ubiquitination of Histone H2B by Proteasome Subunit RPT6 Controls Histone Methylation Chromatin Dynamics During Memory Formation
Sign Up to like & getrecommendations! Published in 2021 at "Biological Psychiatry"
DOI: 10.1016/j.biopsych.2020.12.029
Abstract: BACKGROUND Posttranslational histone modifications play a critical role in the regulation of gene transcription underlying synaptic plasticity and memory formation. One such epigenetic change is histone ubiquitination, a process that is mediated by the ubiquitin-proteasome… read more here.
Keywords: memory formation; histone h2b; histone; memory ... See more keywords
Structural Basis of Dot1L Stimulation by Histone H2B Lysine 120 Ubiquitination.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular cell"
DOI: 10.1016/j.molcel.2019.03.029
Abstract: The essential histone H3 lysine 79 methyltransferase Dot1L regulates transcription and genomic stability and is deregulated in leukemia. The activity of Dot1L is stimulated by mono-ubiquitination of histone H2B on lysine 120 (H2BK120Ub); however, the… read more here.
Keywords: lysine 120; histone h2b; h2b lysine; histone ... See more keywords
Functional Interplay between Histone H2B ADP-Ribosylation and Phosphorylation Controls Adipogenesis.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular cell"
DOI: 10.1016/j.molcel.2020.08.002
Abstract: Although ADP-ribosylation of histones by PARP-1 has been linked to genotoxic stress responses, its role in physiological processes and gene expression has remained elusive. We found that NAD+-dependent ADP-ribosylation of histone H2B-Glu35 by small nucleolar… read more here.
Keywords: adp ribosylation; histone h2b; functional interplay; h2b ... See more keywords
The Effects of Histone H2B Ubiquitylations on the Nucleosome Structure and Internucleosomal Interactions.
Sign Up to like & getrecommendations! Published in 2022 at "Biochemistry"
DOI: 10.1021/acs.biochem.2c00422
Abstract: Eukaryotic gene compaction takes place at multiple levels to package DNA to chromatin and chromosomes. Two of the most fundamental levels of DNA packaging are at the nucleosome and dinucleosome stacks. The nucleosome is the… read more here.
Keywords: structure; histone h2b; h2b ubiquitylations; structure internucleosomal ... See more keywords
Effects of Histone H2B Ubiquitylations and H3K79me3 on Transcription Elongation.
Sign Up to like & getrecommendations! Published in 2023 at "ACS chemical biology"
DOI: 10.1021/acschembio.2c00887
Abstract: Post-translational modifications of histone proteins often mediate gene regulation by altering the global and local stability of the nucleosome, the basic gene-packing unit of eukaryotes. We employed semisynthetic approaches to introduce histone H2B ubiquitylations at… read more here.
Keywords: histone h2b; transcription; transcription elongation; h2b ubiquitylations ... See more keywords
Histone H2B Deacylation Selectivity: Exploring Chromatin’s Dark Matter with an Engineered Sortase
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.1c13555
Abstract: We describe a new method to produce histone H2B by semisynthesis with an engineered sortase transpeptidase. N-Terminal tail site-specifically modified acetylated, lactylated, and β-hydroxybutyrylated histone H2Bs were incorporated into nucleosomes and investigated as substrates of… read more here.
Keywords: chromatin; histone h2b; histone; h2b deacylation ... See more keywords
let-7b and let-7c microRNAs promote histone H2B ubiquitylation and inhibit cell migration by targeting multiple components of the H2B deubiquitylation machinery
Sign Up to like & getrecommendations! Published in 2017 at "Oncogene"
DOI: 10.1038/onc.2017.187
Abstract: Monoubiquitylation of histone H2B (H2Bub1) is catalyzed mainly by the RNF20/RNF40 complex and erased by multiple deubiquitylating enzymes (DUBs). H2Bub1 influences many aspects of chromatin function, including transcription regulation and DNA repair. Cancer cells often… read more here.
Keywords: histone h2b; let let; migration; h2bub1 levels ... See more keywords
Convergent Total Synthesis of Histone H2B Protein with Site-Specific Ubiquitination at Lys120
Sign Up to like & getrecommendations! Published in 2017 at "Synlett"
DOI: 10.1055/s-0036-1590794
Abstract: Histone H2B Lys120 mono-ubiquitylation (H2BK120Ub) plays an important role in regulating gene expression and diverse nuclear processes. For biochemical and biophysical studies of this dynamic post-translational modification, access to homogeneous and workable amount of H2BK120Ub… read more here.
Keywords: convergent total; histone h2b; h2bk120ub; histone ... See more keywords
USP49-Mediated Histone H2B Deubiquitination Regulates HCT116 Cell Proliferation through MDM2-p53 Axis
Sign Up to like & getrecommendations! Published in 2022 at "Molecular and Cellular Biology"
DOI: 10.1128/mcb.00434-21
Abstract: Posttranslational histone modifications play important roles in regulating chromatin structure and transcriptional regulation. Histone H2B monoubiquitination (H2Bub) is an essential regulator for transcriptional elongation and ongoing transcription. ABSTRACT Posttranslational histone modifications play important roles in… read more here.
Keywords: cell proliferation; mdm2; histone h2b; hct116 cell ... See more keywords
A Mutation in Histone H2B Represents a New Class of Oncogenic Driver.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-19-0393
Abstract: By examination of the cancer genomics database we identified a new set of mutations in core histones that frequently recur in cancer patient samples and are predicted to disrupt nucleosome stability. In support of this… read more here.
Keywords: cancer; histone h2b; histone; h2b ... See more keywords
SUN-091 Functional Links between ADP-Ribosylation and Phosphorylation on Histone H2B Regulate Adipocyte Differentiation
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the Endocrine Society"
DOI: 10.1210/js.2019-sun-091
Abstract: Abstract The differentiation of adipocyte precursors (preadipocytes) into mature adipocytes is a complex developmental process involving a carefully orchestrated transcriptional program, which is regulated by post-translational modification (PTM) of key target proteins. Our lab has… read more here.
Keywords: ribosylation; histone h2b; ribosylation phosphorylation; phosphorylation histone ... See more keywords