Methylation of Histone H3K79 by Dot1L Requires Multiple Contacts with the Ubiquitinated Nucleosome.
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DOI: 10.1016/j.molcel.2019.05.013
Abstract: Cryo-EM structures of Dot1L in complex with a ubiquitinated nucleosome provide the long-sought-after molecular mechanism of Dot1L-mediated methylation of lysine 79 in histone H3 and explain crosstalk with histone H2B ubiquitination. read more here.
Keywords: histone h3k79; ubiquitinated nucleosome; methylation histone; histone ... See more keywords