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Histone lactylation

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0 Published in 2019 at "Nature Immunology"

DOI: 10.1038/s41590-019-0551-6

Abstract: The brain has long been considered to be a site of immune privilege; however, it is now increasingly appreciated that immune cells can enter the brain at steady state to exert important physiological effects. In… read more here.

Keywords: histone lactylation; brain; production; immunology ... See more keywords

Histone lactylation driven by mROS-mediated glycolytic shift promotes hypoxic pulmonary hypertension

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1 Published in 2022 at "Journal of Molecular Cell Biology"

DOI: 10.1093/jmcb/mjac073

Abstract: ABSTRACT Increased mitochondrial reactive oxygen species (mROS) and glycolysis have been established in pulmonary hypertension (PH). However, the effect of elevated mROS on glycolytic shift and how increased glycolysis promotes hypoxic pulmonary artery smooth muscle… read more here.

Keywords: promotes hypoxic; pulmonary hypertension; glycolytic shift; lactylation ... See more keywords

Histone Lactylation Boosts Reparative Gene Activation Post–Myocardial Infarction

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1 Published in 2022 at "Circulation Research"

DOI: 10.1161/circresaha.122.320488

Abstract: Background: Inflammation resolution and cardiac repair initiation after myocardial infarction (MI) require timely activation of reparative signals. Histone lactylation confers macrophage homeostatic gene expression signatures via transcriptional regulation. However, the role of histone lactylation in… read more here.

Keywords: histone lactylation; post; lactylation; reparative gene ... See more keywords

Enterobacterial LPS-inducible LINC00152 is regulated by histone lactylation and promotes cancer cells invasion and migration

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1 Published in 2022 at "Frontiers in Cellular and Infection Microbiology"

DOI: 10.3389/fcimb.2022.913815

Abstract: Gut microbes participate in pathogenesis by interacting with the host genome through epigenetic mechanisms, such as long non-coding RNAs. However, the mechanisms by which the microbiota induce expression alteration of long non-coding RNAs remains unclear.… read more here.

Keywords: inducible linc00152; lps inducible; expression; histone lactylation ... See more keywords

The role and mechanism of histone lactylation in health and diseases

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2 Published in 2022 at "Frontiers in Genetics"

DOI: 10.3389/fgene.2022.949252

Abstract: Whether under anaerobic or aerobic conditions, glycolysis results in production of lactate. Increasing evidence suggests that lactate serves as a multifunctional signaling molecule that develops non-metabolic activities in addition to serving as a key metabolite… read more here.

Keywords: lactylation; histone lactylation; role mechanism; mechanism histone ... See more keywords