Analysis of the role of mutations in the KMT2D histone lysine methyltransferase in bladder cancer
Sign Up to like & getrecommendations! Published in 2019 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.12600
Abstract: Histone lysine methyltransferases (HMT) comprise a subclass of epigenetic regulators; dysregulation of these enzymes affects gene expression, which may lead to tumorigenesis. Here, we performed an integrated analysis of 50 HMTs in bladder cancer and… read more here.
Keywords: bladder cancer; histone lysine; analysis; bladder ... See more keywords
Histone lysine methyltransferase SETDB2 suppresses NRF2 to restrict tumor progression and modulates chemotherapy sensitivity in lung adenocarcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Medicine"
DOI: 10.1002/cam4.5451
Abstract: Aberrant epigenetic remodeling represents a molecular hallmark in lung adenocarcinoma (LUAD). We aim to investigate the biological roles of SETDB2 and its underlying associations with oxidative stress, providing therapeutic targets for individualized treatment of LUAD. read more here.
Keywords: methyltransferase setdb2; lung adenocarcinoma; histone lysine; lung ... See more keywords
Histone Lysine-to-Methionine Mutation as Anticancer Drug Target.
Sign Up to like & getrecommendations! Published in 2021 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-15-8104-5_7
Abstract: Histone modification stands for a vital genetic information form, which shows tight correlation with the modulation of normal physiological activities by genes. Abnormal regulation of histone methylation due to histone modification enzyme changes and histone… read more here.
Keywords: methylation; histone lysine; lysine methionine; methionine mutation ... See more keywords
Design, synthesis, anticancer evaluation, molecular docking and cell cycle analysis of 3-methyl-4,7-dihydropyrazolo[1,5-a]pyrimidine derivatives as potent histone lysine demethylases (KDM) inhibitors and apoptosis inducers.
Sign Up to like & getrecommendations! Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2019.102929
Abstract: A novel series of pyrazolo[1,5-a]pyrimidines were synthesized and proved by their spectral and elemental analysis, some elected of the newly synthesized compounds were examined for their cytotoxic activity employing MTT assay on two cancer cell… read more here.
Keywords: histone lysine; analysis; lysine demethylases; cell cycle ... See more keywords
Histone H3 lysine 4 trimethylation in sperm is transmitted to the embryo and associated with diet-induced phenotypes in the offspring.
Sign Up to like & getrecommendations! Published in 2021 at "Developmental cell"
DOI: 10.1016/j.devcel.2021.01.014
Abstract: A father's lifestyle impacts offspring health; yet, the underlying molecular mechanisms remain elusive. We hypothesized that a diet that changes methyl donor availability will alter the sperm and embryo epigenomes to impact embryonic gene expression… read more here.
Keywords: histone lysine; lysine trimethylation; gene expression; transmitted embryo ... See more keywords
Discovery of a potent and selective inhibitor of histone lysine demethylase KDM4D.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2021.113662
Abstract: Histone lysine demethylase 4D (KDM4D) plays an important role in the regulation of tumorigenesis, progression and drug resistance and has been considered a potential target for cancer treatment. However, there is still a lack of… read more here.
Keywords: potent selective; histone lysine; demethylase kdm4d; kdm4d ... See more keywords
Intestinal Inflammation is Linked to Hypoacetylation of Histone 3 Lysine 27 and can be Reversed by Valproic Acid Treatment in Inflammatory Bowel Disease Patients
Sign Up to like & getrecommendations! Published in 2020 at "Cellular and Molecular Gastroenterology and Hepatology"
DOI: 10.1016/j.jcmgh.2020.11.009
Abstract: Benefits from biologic therapy for inflammatory bowel disease (IBD) come at a cost of side effects and antidrug antibodies. This necessitates novel anti-inflammatory therapies. Histone acetylation is an important epigenetic gene expression regulator. Acetylation of… read more here.
Keywords: bowel disease; histone lysine; inflammatory bowel; inflammation ... See more keywords
Cancer-associated 2-oxoglutarate analogues modify histone methylation by inhibiting histone lysine demethylases.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2018.06.048
Abstract: Histone lysine demethylases (KDMs) are 2-oxoglutarate-dependent dioxygenases (2-OGDDs) that regulate gene expression by altering chromatin structure. Their dysregulation has been associated with many cancers. We set out to study the catalytic and inhibitory properties of… read more here.
Keywords: associated oxoglutarate; histone lysine; lysine demethylases; cancer ... See more keywords
A unique histone 3 lysine 14 chromatin signature underlies tissue-specific gene regulation.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular cell"
DOI: 10.1016/j.molcel.2021.01.041
Abstract: Organismal development and cell differentiation critically depend on chromatin state transitions. However, certain developmentally regulated genes lack histone 3 lysine 9 and 27 acetylation (H3K9ac and H3K27ac, respectively) and histone 3 lysine 4 (H3K4) methylation,… read more here.
Keywords: tissue specific; histone lysine; lysine; specific gene ... See more keywords
Broad domains of histone 3 lysine 4 trimethylation are associated with transcriptional activation in CA1 neurons of the hippocampus during memory formation
Sign Up to like & getrecommendations! Published in 2019 at "Neurobiology of Learning and Memory"
DOI: 10.1016/j.nlm.2019.04.009
Abstract: Transcriptional changes in the hippocampus are required for memory formation, and these changes are regulated by numerous post-translational modifications of chromatin-associated proteins. One of the epigenetic marks that has been implicated in memory formation is… read more here.
Keywords: memory formation; histone lysine; lysine trimethylation; h3k4me3 ... See more keywords
Prenatal nicotine exposure leads to decreased histone H3 lysine 9 (H3K9) methylation and increased p66shc expression in the neonatal pancreas
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Developmental Origins of Health and Disease"
DOI: 10.1017/s2040174421000283
Abstract: Abstract Prenatal exposure to nicotine, tobacco’s major addictive constituent, has been shown to reduce birth weight and increases apoptosis, oxidative stress, and mitochondrial dysfunction in the postnatal pancreas. Given that upregulated levels of the pro-oxidative… read more here.
Keywords: expression; p66shc expression; increased p66shc; histone lysine ... See more keywords