Nutrient Sensing by Histone Marks: Reading the Metabolic Histone Code Using Tracing, Omics, and Modeling
Sign Up to like & getrecommendations! Published in 2020 at "BioEssays"
DOI: 10.1002/bies.202000083
Abstract: Several metabolites serve as substrates for histone modifications and communicate changes in the metabolic environment to the epigenome. Technologies such as metabolomics and proteomics have allowed us to reconstruct the interactions between metabolic pathways and… read more here.
Keywords: sensing histone; reading metabolic; histone marks; marks reading ... See more keywords
Collective regulation of chromatin modifications predicts replication timing during cell cycle
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.109799
Abstract: SUMMARY Replication timing (RT) associates with genome architecture, while having a mixed relationship to histone marks. By profiling replication at high resolution and assessing broad histone marks across the cell cycle at the resolution of… read more here.
Keywords: cell; chromatin; replication timing; histone marks ... See more keywords
Bivalent recognition of histone marks by BARD1.
Sign Up to like & getrecommendations! Published in 2021 at "Trends in cell biology"
DOI: 10.1016/j.tcb.2021.06.005
Abstract: BARD1 directs BRCA1 to DNA damage sites to facilitate homology recombination. Zhou and colleagues have now determined the cryo-electron microscopy (cryo-EM) structure of BARD1 bound to a nucleosome core particle with two marks: H2AK15ub and… read more here.
Keywords: histone marks; recognition; marks bard1; recognition histone ... See more keywords
Decoding regulatory structures and features from epigenomics profiles: a Roadmap-ENCODE Variational Auto-Encoder (RE-VAE) model.
Sign Up to like & getrecommendations! Published in 2019 at "Methods"
DOI: 10.1016/j.ymeth.2019.10.012
Abstract: The development of chromatin immunoprecipitation (ChIP) with massively parallel DNA sequencing (ChIP-seq) technologies has promoted generation of large-scale epigenomics data, providing us unprecedented opportunities to explore the landscape of epigenomic profiles at scales across both… read more here.
Keywords: histone marks; auto encoder; variational auto; vae model ... See more keywords
Deciphering the Interactome of Histone Marks in Living Cells via Genetic Code Expansion Combined with Proximity Labeling.
Sign Up to like & getrecommendations! Published in 2022 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.2c01042
Abstract: Deciphering the endogenous interactors of histone post-translational modifications (hPTMs, also called histone marks) is essential to understand the mechanisms of epigenetic regulation. However, most of the analytical methods to determine hPTM interactomes are in vitro… read more here.
Keywords: histone marks; histone; genetic code; code expansion ... See more keywords
Grape ASR-Silencing Sways Nuclear Proteome, Histone Marks and Interplay of Intrinsically Disordered Proteins
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23031537
Abstract: In order to unravel the functions of ASR (Abscisic acid, Stress, Ripening-induced) proteins in the nucleus, we created a new model of genetically transformed grape embryogenic cells by RNAi-knockdown of grape ASR (VvMSA). Nuclear proteomes… read more here.
Keywords: histone marks; intrinsically disordered; grape asr; vvmsa ... See more keywords
Histone Marks-Dependent Effect on Alternative Splicing: New Perspectives for Targeted Splicing Modulation in Cancer?
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23158304
Abstract: Alternative splicing (AS) is a tightly regulated mechanism that generates the complex human proteome from a small number of genes. Cis-regulatory RNA motifs in exons and introns control AS, recruiting positive and negative trans-acting splicing… read more here.
Keywords: histone marks; effect; histone; modulation ... See more keywords
Proteasome activator PA200 maintains stability of histone marks during transcription and aging
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DOI: 10.7150/thno.48744
Abstract: The epigenetic inheritance relies on stability of histone marks, but various diseases, including aging-related disorders, are usually associated with alterations of histone marks. Whether and how the proteasome is responsible for maintaining the histone marks… read more here.
Keywords: marks transcription; transcription; stability histone; pa200 ... See more keywords